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- W2023247493 abstract "Importance of making available selective adenosine receptor antagonists is boosted by recent findings of adenosine involvement in many CNS dysfunctions. In the present work a series of 8-bromo-9-alkyl adenines are prepared and fully characterized in radioligand binding assays or functional cyclase experiments in respect to their interaction with all the four adenosine receptor subtypes. Results show that the presence of the bromine atom in 8-position of 9-substituted adenines promotes in general the interaction with the adenosine receptors, in particular at the A2A subtype. The present study also demonstrates that adenine derivatives could be a good starting point to obtain selective adenosine A2B receptor antagonists." @default.
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- W2023247493 date "2009-04-01" @default.
- W2023247493 modified "2023-10-15" @default.
- W2023247493 title "8-Bromo-9-alkyl adenine derivatives as tools for developing new adenosine A2A and A2B receptors ligands" @default.
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- W2023247493 doi "https://doi.org/10.1016/j.bmc.2009.02.030" @default.
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