FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023247504> ?p ?o ?g. }

• W2023247504 endingPage "136" @default.
• W2023247504 startingPage "127" @default.
• W2023247504 abstract "The effects of the thyroid hormones on target cells are mediated through nuclear T3 receptors. In the peripheral nervous system, nuclear T3 receptors were previously detected with the monoclonal antibody 283 rnAb in all the primary sensory neurons throughout neuronal life and in peripheral glia at the perinatal period only (Eur. J. Neurosci. 5, 379, 7993). To determine whether these nuclear T3 receptors correspond to functional ones able to bind T3, cryostat sections and in vitro cell cultures of dorsal root ganglion (DRG) or sciatic nerve were incubated with 0.1 nM [1251]-labeled T3, either alone to visualize the total T3-binding sites or added with a lo3 fold excess of unlabeled T3 to estimate the part due to the non-specific T3-binding. After glutaraldehyde fixation, radioautography showed that the specific T3-binding sites were largely prevalent. The T3-binding capacity of peripheral glia in DRG and sciatic nerve was restricted to the perinatal period in vivo and to Schwann cells cultured in vitro. In all the primary sensory neurons, specific T3-binding sites were disclosed in foetal as well as adult rats. The detection of the T3-binding sites in the nucleus indicated that the nuclear T3 receptors are functional. Moreover the concomitant presence of both T3-binding sites and T3 receptors CI isoforms in the perikaryon of DRG neurons infers that: 1) [1251]-labeied T3 can be retained on the T3-binding ‘E’ domain of nascent CI, isoform molecules newly-synthesized on the perikaryal ribosomes; 2) the CI isoforms translocated to the nucleus are modified by posttranslational changes and finally recognized by 2B3 rnAb as nuclear T3 receptor. In conclusion, the radioautographic visualization of the T3-binding sites in peripheral neurons and glia confirms that the nuclear T3 receptors are functional and contributes to clarify t h e discordant intracellular localization provided by the immunocytochemical detection of nuclear T3 receptors and T3 receptor CI isoforms." @default.
• W2023247504 created "2016-06-24" @default.
• W2023247504 creator A5025330525 @default.
• W2023247504 creator A5080670685 @default.
• W2023247504 date "1995-02-01" @default.
• W2023247504 modified "2023-09-26" @default.
• W2023247504 title "Nuclear and Cytoplasmic Triiodothyronine-Binding Sites in Primary Sensory Neurons and Schwann Cells: Radioautographic Study During Development" @default.
• W2023247504 cites W1519641819 @default.
• W2023247504 cites W1565068678 @default.
• W2023247504 cites W1965071308 @default.
• W2023247504 cites W1968439760 @default.
• W2023247504 cites W1968791286 @default.
• W2023247504 cites W1983450433 @default.
• W2023247504 cites W1986006697 @default.
• W2023247504 cites W1990710314 @default.
• W2023247504 cites W1995848424 @default.
• W2023247504 cites W2002104445 @default.
• W2023247504 cites W2005586596 @default.
• W2023247504 cites W2011101649 @default.
• W2023247504 cites W2027096867 @default.
• W2023247504 cites W2028765085 @default.
• W2023247504 cites W2028800853 @default.
• W2023247504 cites W2029071523 @default.
• W2023247504 cites W2034321621 @default.
• W2023247504 cites W2036931125 @default.
• W2023247504 cites W2042545104 @default.
• W2023247504 cites W2058232931 @default.
• W2023247504 cites W2064122825 @default.
• W2023247504 cites W2066958968 @default.
• W2023247504 cites W2078957859 @default.
• W2023247504 cites W2083095165 @default.
• W2023247504 cites W2088392113 @default.
• W2023247504 cites W2093696804 @default.
• W2023247504 cites W2108726742 @default.
• W2023247504 cites W2168054990 @default.
• W2023247504 cites W280855627 @default.
• W2023247504 cites W3020899620 @default.
• W2023247504 cites W4230313631 @default.
• W2023247504 cites W4234962771 @default.
• W2023247504 cites W4241789598 @default.
• W2023247504 cites W99769449 @default.
• W2023247504 doi "https://doi.org/10.1111/j.1365-2826.1995.tb00675.x" @default.
• W2023247504 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7767325" @default.
• W2023247504 hasPublicationYear "1995" @default.
• W2023247504 type Work @default.
• W2023247504 sameAs 2023247504 @default.
• W2023247504 citedByCount "21" @default.
• W2023247504 countsByYear W20232475042013 @default.
• W2023247504 countsByYear W20232475042015 @default.
• W2023247504 countsByYear W20232475042016 @default.
• W2023247504 countsByYear W20232475042017 @default.
• W2023247504 countsByYear W20232475042018 @default.
• W2023247504 crossrefType "journal-article" @default.
• W2023247504 hasAuthorship W2023247504A5025330525 @default.
• W2023247504 hasAuthorship W2023247504A5080670685 @default.
• W2023247504 hasConcept C105702510 @default.
• W2023247504 hasConcept C126322002 @default.
• W2023247504 hasConcept C134018914 @default.
• W2023247504 hasConcept C169760540 @default.
• W2023247504 hasConcept C170493617 @default.
• W2023247504 hasConcept C2775908076 @default.
• W2023247504 hasConcept C2776281502 @default.
• W2023247504 hasConcept C2781149210 @default.
• W2023247504 hasConcept C55493867 @default.
• W2023247504 hasConcept C71924100 @default.
• W2023247504 hasConcept C86803240 @default.
• W2023247504 hasConcept C94487597 @default.
• W2023247504 hasConcept C95444343 @default.
• W2023247504 hasConceptScore W2023247504C105702510 @default.
• W2023247504 hasConceptScore W2023247504C126322002 @default.
• W2023247504 hasConceptScore W2023247504C134018914 @default.
• W2023247504 hasConceptScore W2023247504C169760540 @default.
• W2023247504 hasConceptScore W2023247504C170493617 @default.
• W2023247504 hasConceptScore W2023247504C2775908076 @default.
• W2023247504 hasConceptScore W2023247504C2776281502 @default.
• W2023247504 hasConceptScore W2023247504C2781149210 @default.
• W2023247504 hasConceptScore W2023247504C55493867 @default.
• W2023247504 hasConceptScore W2023247504C71924100 @default.
• W2023247504 hasConceptScore W2023247504C86803240 @default.
• W2023247504 hasConceptScore W2023247504C94487597 @default.
• W2023247504 hasConceptScore W2023247504C95444343 @default.
• W2023247504 hasIssue "2" @default.
• W2023247504 hasLocation W20232475041 @default.
• W2023247504 hasLocation W20232475042 @default.
• W2023247504 hasOpenAccess W2023247504 @default.
• W2023247504 hasPrimaryLocation W20232475041 @default.
• W2023247504 hasRelatedWork W1522443191 @default.
• W2023247504 hasRelatedWork W2001168847 @default.
• W2023247504 hasRelatedWork W2006607961 @default.
• W2023247504 hasRelatedWork W2132254207 @default.
• W2023247504 hasRelatedWork W2157916066 @default.
• W2023247504 hasRelatedWork W2382832542 @default.
• W2023247504 hasRelatedWork W2410213952 @default.
• W2023247504 hasRelatedWork W2460981064 @default.
• W2023247504 hasRelatedWork W2469360523 @default.
• W2023247504 hasRelatedWork W3032146920 @default.
• W2023247504 hasVolume "7" @default.
• W2023247504 isParatext "false" @default.

• next