Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023248002> ?p ?o ?g. }
- W2023248002 abstract "The nervous system is a steroidogenic tissue and several steroids synthesized locally in the brain, such as pregnenolone, progesterone and estradiol, modulate neuronal and glial physiology and are neuroprotective. The brain upregulates steroidogenesis at sites of injury as part of a program triggered by neural tissue to cope with neurodegenerative insults. Pharmacological targets to increase brain steroidogenesis and promote neuroprotection include the molecules that transport cholesterol to the inner mitochondrial membrane, where the first enzyme for steroidogenesis is located. Furthermore, the human gene encoding aromatase, the enzyme that synthesizes estradiol, is under the control of different tissue-specific promoters, and it is therefore conceivable that selective aromatase modulators can be developed that will enhance the expression of the enzyme and the consequent increase in estrogen formation in the brain but not in other tissues." @default.
- W2023248002 created "2016-06-24" @default.
- W2023248002 creator A5025650833 @default.
- W2023248002 creator A5057589065 @default.
- W2023248002 creator A5071313567 @default.
- W2023248002 creator A5083968750 @default.
- W2023248002 date "2010-01-01" @default.
- W2023248002 modified "2023-10-18" @default.
- W2023248002 title "Therapeutic implications of brain steroidogenesis" @default.
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- W2023248002 doi "https://doi.org/10.1515/hmbci.2010.003" @default.
- W2023248002 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25961968" @default.
- W2023248002 hasPublicationYear "2010" @default.
- W2023248002 type Work @default.