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- W2023249426 abstract "Trials have revealed that cardiovascular risk is not uniform in the population, but is distributed in a risk pyramid. Diabetic patients with prior cardiovascular disease (CVD) are at greatest risk. Nondiabetic patients with CVD, diabetic patients without CVD, and subjects with the metabolic syndrome form the next three risk categories. The presence of insulin resistance-related metabolic abnormalities is a common denominator in this risk pyramid. Insulin resistance is a core defect in type 2 diabetes and the metabolic syndrome. Because insulin resistance may cause the atherogenic dyslipidemia that is commonly associated with these conditions, therapeutic strategies that combat insulin resistance could substantially reduce cardiovascular risk. Evidence suggests that defects in mitochondrial oxidative phosphorylation (which may be inherited, age related, or lifestyle acquired) may play a critical role in the pathogenesis of insulin resistance. Reduced mitochondrial oxidative phosphorylation can be partially reversed by improved diet, increased exercise, and administration of peroxisome proliferator-activated receptor-α agonists (ω-3 fatty acids and fibrates). Statin therapy has demonstrated clinical benefits in insulin-resistant patients but residual cardiovascular risk remains elevated. Fibrates also improve the lipid profile and reduce cardiovascular risk in a variety of insulin-resistant populations. Affected individuals should be targeted for therapeutic lifestyle intervention. Patients with atherogenic dyslipidemia who have developed insulin resistance, the metabolic syndrome, or type 2 diabetes should receive more intensive interventions including, where appropriate, statin–fibrate combination therapy, to comprehensively modify the lipid profile together with aggressive control of blood pressure and glucose to minimize risk in this very high-risk population." @default.
- W2023249426 created "2016-06-24" @default.
- W2023249426 creator A5055380940 @default.
- W2023249426 creator A5087338641 @default.
- W2023249426 date "2006-12-01" @default.
- W2023249426 modified "2023-10-17" @default.
- W2023249426 title "New Concepts in Dyslipidemia in the Metabolic Syndrome and Diabetes" @default.
- W2023249426 cites W1500963439 @default.
- W2023249426 cites W1527237994 @default.
- W2023249426 cites W1647126819 @default.
- W2023249426 cites W1874374293 @default.
- W2023249426 cites W1961916049 @default.
- W2023249426 cites W1965006643 @default.
- W2023249426 cites W1971082641 @default.
- W2023249426 cites W1973842058 @default.
- W2023249426 cites W1978568726 @default.
- W2023249426 cites W1990166147 @default.
- W2023249426 cites W1991659881 @default.
- W2023249426 cites W1991795789 @default.
- W2023249426 cites W1996821192 @default.
- W2023249426 cites W1997631312 @default.
- W2023249426 cites W2001751639 @default.
- W2023249426 cites W2005052233 @default.
- W2023249426 cites W2012898950 @default.
- W2023249426 cites W2015873233 @default.
- W2023249426 cites W2017582082 @default.
- W2023249426 cites W2020267609 @default.
- W2023249426 cites W2021593489 @default.
- W2023249426 cites W2024144186 @default.
- W2023249426 cites W2027670788 @default.
- W2023249426 cites W2031185570 @default.
- W2023249426 cites W2031484324 @default.
- W2023249426 cites W2042875425 @default.
- W2023249426 cites W2043092726 @default.
- W2023249426 cites W2044428655 @default.
- W2023249426 cites W2045054080 @default.
- W2023249426 cites W2045622064 @default.
- W2023249426 cites W2049481764 @default.
- W2023249426 cites W2051583212 @default.
- W2023249426 cites W2054851194 @default.
- W2023249426 cites W2060431825 @default.
- W2023249426 cites W2060564120 @default.
- W2023249426 cites W2062476040 @default.
- W2023249426 cites W2067097172 @default.
- W2023249426 cites W2070336409 @default.
- W2023249426 cites W2079872539 @default.
- W2023249426 cites W2090895117 @default.
- W2023249426 cites W2091671727 @default.
- W2023249426 cites W2092441434 @default.
- W2023249426 cites W2095885613 @default.
- W2023249426 cites W2098690816 @default.
- W2023249426 cites W2099789671 @default.
- W2023249426 cites W2100779832 @default.
- W2023249426 cites W2101725562 @default.
- W2023249426 cites W2102906564 @default.
- W2023249426 cites W2103714496 @default.
- W2023249426 cites W2106343349 @default.
- W2023249426 cites W2107295258 @default.
- W2023249426 cites W2107945166 @default.
- W2023249426 cites W2108462699 @default.
- W2023249426 cites W2108886453 @default.
- W2023249426 cites W2112375566 @default.
- W2023249426 cites W2115830695 @default.
- W2023249426 cites W2120282127 @default.
- W2023249426 cites W2121209370 @default.
- W2023249426 cites W2122857181 @default.
- W2023249426 cites W2123106337 @default.
- W2023249426 cites W2123289485 @default.
- W2023249426 cites W2125094939 @default.
- W2023249426 cites W2126115073 @default.
- W2023249426 cites W2126317966 @default.
- W2023249426 cites W2127307547 @default.
- W2023249426 cites W2130850001 @default.
- W2023249426 cites W2137693160 @default.
- W2023249426 cites W2141486394 @default.
- W2023249426 cites W2142167397 @default.
- W2023249426 cites W2144692487 @default.
- W2023249426 cites W2145531404 @default.
- W2023249426 cites W2147176408 @default.
- W2023249426 cites W2148562280 @default.
- W2023249426 cites W2152530907 @default.
- W2023249426 cites W2158049568 @default.
- W2023249426 cites W2159969745 @default.
- W2023249426 cites W2160689800 @default.
- W2023249426 cites W2166606079 @default.
- W2023249426 cites W2166961959 @default.
- W2023249426 cites W2167285869 @default.
- W2023249426 cites W2168561379 @default.
- W2023249426 cites W2169033201 @default.
- W2023249426 cites W2169121622 @default.
- W2023249426 cites W2171569022 @default.
- W2023249426 cites W2198678228 @default.
- W2023249426 cites W2328529137 @default.
- W2023249426 cites W2337133379 @default.
- W2023249426 cites W2400712338 @default.
- W2023249426 cites W2601704071 @default.
- W2023249426 cites W4205288846 @default.
- W2023249426 cites W4232051691 @default.