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- W2023249940 abstract "The in vitro release of indomethacin from 1%, 3%, and 5% indomethacin ointments and its in vivo absorption through the skin of rabbits was investigated. The in vitro release of indomethacin followed zero-order kinetics and was better from an absorption base ointment. No significant differences (F=3.047 and P=0.079 for the absorption base) and (F=2.15 and P=0.14 for the hydrophilic base) in the release rate of indomethacin in 1%, 3%, and 5% indomethacin ointments were observed. Indomethacin was most effectively absorbed from absorption ointment bases. A correlation between the in vitro release and the in vivo absorption was found; also, a correlation between the in vivo release pattern of the bases used and the in vivo data reported in the literature was observed." @default.
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- W2023249940 date "1984-01-01" @default.
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- W2023249940 title "Medicament Release from Ointment Bases: I. Indomethacin. In Vitro and in Vivo Release Studies" @default.
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- W2023249940 doi "https://doi.org/10.3109/03639048409038306" @default.
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