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- W2023250228 abstract "The purpose of the present investigation was to determine the feasibility of using lysolipid-based thermal sensitive liposomes (145 nm) for high molecular weight molecule delivery. Fluorescein isothiocyanate conjugate-albumin was used as a model drug (MW 66 kDa). Thermal sensitive liposomes, which encapsulated the protein were prepared using a passive encapsulation methodology involving freeze-thawing cycles followed by extrusion. In vitro release studies at various temperatures indicated rapid release behaviour of the encapsulated protein at 42 and 44.5 °C but a good stability at 37.5 °C. The current findings suggest that lysolipid-based thermal sensitive liposomes can be used to deliver high molecular weight molecules." @default.
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- W2023250228 date "2011-12-01" @default.
- W2023250228 modified "2023-09-27" @default.
- W2023250228 title "Development of lysolipid-based thermosensitive liposomes for delivery of high molecular weight proteins" @default.
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- W2023250228 doi "https://doi.org/10.1016/j.ijpharm.2011.09.016" @default.
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