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- W2023250597 abstract "Induction of Foxp3 gene expression and acquisition of regulatory T cell fate is, understandably, a highly controlled process and one which many investigators want to illuminate. In studying the regulation of Foxp3 gene expression, several conserved non-coding regions have been identified and the role of various transcription factors at these sites has been explored. What emerges is that many factors, some positive, some negative, interact to collectively drive Foxp3 gene expression and then maintain its expression in Foxp3(+) regulatory T cells. TCR signaling is imperative for Foxp3 gene expression and TGF-β is a key cytokine for initiating Foxp3 gene expression in naïve T cells. But other signaling pathways are also known to play a role in properly orchestrating Foxp3 gene expression and regulatory T cell expansion. Here we review the recent progress in understanding the complex molecular events that drive Foxp3 gene expression and allow functional regulatory T cells to develop." @default.
- W2023250597 created "2016-06-24" @default.
- W2023250597 creator A5010549225 @default.
- W2023250597 creator A5025752056 @default.
- W2023250597 creator A5031483837 @default.
- W2023250597 creator A5067207569 @default.
- W2023250597 date "2011-12-01" @default.
- W2023250597 modified "2023-10-08" @default.
- W2023250597 title "The molecular mechanisms of Foxp3 gene regulation" @default.
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- W2023250597 doi "https://doi.org/10.1016/j.smim.2011.06.005" @default.
- W2023250597 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3205321" @default.
- W2023250597 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21752667" @default.
- W2023250597 hasPublicationYear "2011" @default.
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