Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023251929> ?p ?o ?g. }
- W2023251929 endingPage "687" @default.
- W2023251929 startingPage "677" @default.
- W2023251929 abstract "Besides controlling a wide variety of cell functions, T-type channels have been shown to regulate neurotransmitter release in peripheral and central synapses and neuroendocrine cells. Growing evidence over the last 10 years suggests a key role of Cav3.2 and Cav3.1 channels in controlling basal neurosecretion near resting conditions and sustained release during mild stimulations. In some cases, the contribution of low-voltage-activated (LVA) channels is not directly evident but requires either the activation of coupled presynaptic receptors, block of ion channels, or chelation of metal ions. Concerning the coupling to the secretory machinery, T-type channels appear loosely coupled to neurotransmitter and hormone release. In neurons, Cav3.2 and Cav3.1 channels mainly control the asynchronous appearance of minis [miniature inhibitory postsynaptic currents (mIPSCs) and miniature excitatory postsynaptic currents (mEPSCs)]. The same loose coupling is evident from membrane capacity and amperometric recordings in chromaffin cells and melanotropes where the low-threshold-driven exocytosis possesses the same linear Ca(2+) dependence of the other voltage-gated Ca(2+) channels (Cav1 and Cav2) that is strongly attenuated by slow calcium buffers. The intriguing issue is that, despite not expressing a consensus synprint site, Cav3.2 channels do interact with syntaxin 1A and SNAP-25 and, thus, may form nanodomains with secretory vesicles that can be regulated at low voltages. In this review, we discuss all the past and recent issues related to T-type channel-secretion coupling in neurons and neuroendocrine cells." @default.
- W2023251929 created "2016-06-24" @default.
- W2023251929 creator A5031177031 @default.
- W2023251929 creator A5060746359 @default.
- W2023251929 creator A5085099695 @default.
- W2023251929 date "2014-03-06" @default.
- W2023251929 modified "2023-10-14" @default.
- W2023251929 title "T-type channel-mediated neurotransmitter release" @default.
- W2023251929 cites W1507561445 @default.
- W2023251929 cites W1519856529 @default.
- W2023251929 cites W1524201323 @default.
- W2023251929 cites W1539188443 @default.
- W2023251929 cites W1540396301 @default.
- W2023251929 cites W1568931203 @default.
- W2023251929 cites W1577359560 @default.
- W2023251929 cites W1584902624 @default.
- W2023251929 cites W1675781162 @default.
- W2023251929 cites W1798558936 @default.
- W2023251929 cites W1799107001 @default.
- W2023251929 cites W1845250825 @default.
- W2023251929 cites W1967966322 @default.
- W2023251929 cites W1968392714 @default.
- W2023251929 cites W1969373823 @default.
- W2023251929 cites W1970249565 @default.
- W2023251929 cites W1971190604 @default.
- W2023251929 cites W1972795709 @default.
- W2023251929 cites W1974758589 @default.
- W2023251929 cites W1975571417 @default.
- W2023251929 cites W1975767206 @default.
- W2023251929 cites W1979675387 @default.
- W2023251929 cites W1979752294 @default.
- W2023251929 cites W1982030800 @default.
- W2023251929 cites W1982205433 @default.
- W2023251929 cites W1984675191 @default.
- W2023251929 cites W1986427441 @default.
- W2023251929 cites W1988510192 @default.
- W2023251929 cites W1988800670 @default.
- W2023251929 cites W1990235376 @default.
- W2023251929 cites W1991809199 @default.
- W2023251929 cites W1992753161 @default.
- W2023251929 cites W1996618398 @default.
- W2023251929 cites W1998518207 @default.
- W2023251929 cites W2001679027 @default.
- W2023251929 cites W2003234083 @default.
- W2023251929 cites W2004160272 @default.
- W2023251929 cites W2006251786 @default.
- W2023251929 cites W2012009579 @default.
- W2023251929 cites W2012774316 @default.
- W2023251929 cites W2016591645 @default.
- W2023251929 cites W2017656839 @default.
- W2023251929 cites W2017847991 @default.
- W2023251929 cites W2020914807 @default.
- W2023251929 cites W2023638493 @default.
- W2023251929 cites W2024870161 @default.
- W2023251929 cites W2024958741 @default.
- W2023251929 cites W2025724809 @default.
- W2023251929 cites W2029767812 @default.
- W2023251929 cites W2030315404 @default.
- W2023251929 cites W2032237431 @default.
- W2023251929 cites W2033815363 @default.
- W2023251929 cites W2033866317 @default.
- W2023251929 cites W2036985062 @default.
- W2023251929 cites W2037349520 @default.
- W2023251929 cites W2037908792 @default.
- W2023251929 cites W2038572668 @default.
- W2023251929 cites W2044362463 @default.
- W2023251929 cites W2047397502 @default.
- W2023251929 cites W2052006707 @default.
- W2023251929 cites W2052458078 @default.
- W2023251929 cites W2057430850 @default.
- W2023251929 cites W2058518061 @default.
- W2023251929 cites W2060298909 @default.
- W2023251929 cites W2063934960 @default.
- W2023251929 cites W2064922574 @default.
- W2023251929 cites W206721210 @default.
- W2023251929 cites W2070714075 @default.
- W2023251929 cites W2071848758 @default.
- W2023251929 cites W2072445788 @default.
- W2023251929 cites W2074797643 @default.
- W2023251929 cites W2075522551 @default.
- W2023251929 cites W2078706204 @default.
- W2023251929 cites W2084567756 @default.
- W2023251929 cites W2089228070 @default.
- W2023251929 cites W2092902556 @default.
- W2023251929 cites W2094226862 @default.
- W2023251929 cites W2095352259 @default.
- W2023251929 cites W2096106436 @default.
- W2023251929 cites W2096458210 @default.
- W2023251929 cites W2099329149 @default.
- W2023251929 cites W2101195607 @default.
- W2023251929 cites W2105445497 @default.
- W2023251929 cites W2106326175 @default.
- W2023251929 cites W2110195051 @default.
- W2023251929 cites W2112015090 @default.
- W2023251929 cites W2112155455 @default.
- W2023251929 cites W2123780846 @default.
- W2023251929 cites W2124467099 @default.
- W2023251929 cites W2126992834 @default.