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- W2023254442 abstract "HomeHypertensionVol. 5, No. 3Canine neonatally induced coarctation hypertension in the second year. Variably hyperresponsive plasma renin activity. Free AccessAbstractPDF/EPUBAboutView PDFSections ToolsAdd to favoritesDownload citationsTrack citationsPermissions ShareShare onFacebookTwitterLinked InMendeleyReddit Jump toFree AccessAbstractPDF/EPUBCanine neonatally induced coarctation hypertension in the second year. Variably hyperresponsive plasma renin activity. S P Bagby and G M Baur S P BagbyS P Bagby Search for more papers by this author and G M BaurG M Baur Search for more papers by this author Originally published1 May 1983https://doi.org/10.1161/01.HYP.5.3.328Hypertension. 1983;5:328–335AbstractIn canine neonatally-induced coarctation hypertension, we reported abnormally elevated plasma renin activity (PRA) during sodium restriction in 2-year-old dogs, but found normal PRA responses to sodium restriction +/- furosemide in coarcted dogs studied serially over the first year postaortic banding (PAB). To resolve this apparent discrepancy in PRA response, longitudinal studies were extended to 2 years PAB. In two separately-studied groups, each with three coarcted and three littermate controls, measurements of indirect forelimb blood pressure (BP) at 15 to 18 months, direct brachial arterial BP at 24 months, and serial measurement of PRA and extracellular volume (ECV, as 24Na space) were made over a 15- to 24-month age range during three sodium-volume levels: ad libitum sodium intake (NS), low-sodium diet alone (LS), and low-sodium plus Lasix (LS/Lasix). While PRA in coarcted dogs of both groups was comparable to controls at NS and LS, PRA in Group 1 coarcted dogs significantly exceeded that of littermates during LS/Lasix in both 18- and 24-month studies. In contrast, PRA in Group 2 coarcted dogs was not hyperresponsive to LS/Lasix as compared to simultaneously-studied littermates. The hyperresponsive PRA in Group 1 coarcted dogs could not be attributed to larger absolute or relative ECV deficits. Overall, ECV in coarcted dogs of each group was higher on the average but was not statistically different from controls. Results indicate that the hyperresponsive PRA in this canine model is: 1) a variable feature, developing secondarily in the late established phase; 2) reproducible for a given animal; and 3) not attributed to exaggerated ECV deficits during the LS/Lasix protocol. Previous Back to top Next FiguresReferencesRelatedDetailsCited ByClements M, Banes A and Faber J (1997) Effect of Mechanical Loading on Vascular α1D- and α1B-Adrenergic Receptor Expression, Hypertension, 29:5, (1156-1164), Online publication date: 1-May-1997.Bagby S and Fuchs E (1989) Chronic MK421 fails to modify evolution of hypertension in neonatally coarcted pups., Hypertension, 13:2, (91-101), Online publication date: 1-Feb-1989.Stanek K, Coleman T and Murphy W (1987) Overall hemodynamic pattern in coarctation of the abdominal aorta in conscious rats., Hypertension, 9:6, (611-618), Online publication date: 1-Jun-1987. May 1983Vol 5, Issue 3 Advertisement Article InformationMetrics Copyright © 1983 by American Heart Associationhttps://doi.org/10.1161/01.HYP.5.3.328PMID: 6341218 Originally publishedMay 1, 1983 PDF download Advertisement" @default.
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- W2023254442 title "Canine neonatally induced coarctation hypertension in the second year. Variably hyperresponsive plasma renin activity." @default.
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