FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023255442> ?p ?o ?g. }

• W2023255442 abstract "During recent decades, clinical research has provided a variety of pharmacological substances that can effectively ameliorate the symptoms of Parkinson’s disease (PD), among them selective monoamine oxidase type B inhibitors such as selegiline and rasagiline. Although the latter two substances are nowadays broadly used in clinical practice for monotherapy in early PD and for adjunct therapy to levodopa in advanced PD, there is still uncertainty amongst neurologists whether selegiline or rasagiline should be preferred for antiparkinsonian therapy, since clinical studies directly comparing the efficacy of both compounds on motor and non-motor symptoms are lacking. This article aims to systematically compare the effects of selegiline and rasagiline as monotherapy in early PD and as adjunct treatment in advanced PD with motor fluctuations that have been measured in previous placebo-controlled, double-blind clinical trials and provides an overview about their potential benefits on non-motor symptoms of the disease. In early PD, monotherapy with selegiline and rasagiline provides similar symptomatic efficacy and can be classified as clinically useful for amelioration of emerging motor symptoms. Whereas rasagiline has also demonstrated symptomatic efficacy in patients with advanced PD and can moreover be regarded as efficacious for the treatment of motor fluctuations, the scientific evidence for selegiline in these indications is still insufficient. The available data for both compounds are insufficient to provide a clear picture of their effects on NMS, but recent studies and post hoc analyses provide first evidence for positive actions of rasagiline on fatigue and some aspects of attention and executive functions in non-demented PD patients." @default.
• W2023255442 created "2016-06-24" @default.
• W2023255442 creator A5039229902 @default.
• W2023255442 creator A5069978273 @default.
• W2023255442 date "2012-12-01" @default.
• W2023255442 modified "2023-10-05" @default.
• W2023255442 title "Effects of monoamine oxidase Type B inhibitors on motor and non-motor symptoms in Parkinson’s disease: A systematic comparison of rasagiline and selegiline" @default.
• W2023255442 cites W1968022465 @default.
• W2023255442 cites W1974352826 @default.
• W2023255442 cites W1981420116 @default.
• W2023255442 cites W1987655773 @default.
• W2023255442 cites W1988848669 @default.
• W2023255442 cites W1993831043 @default.
• W2023255442 cites W2000450717 @default.
• W2023255442 cites W2010011015 @default.
• W2023255442 cites W2014736569 @default.
• W2023255442 cites W2016388476 @default.
• W2023255442 cites W2016974396 @default.
• W2023255442 cites W2020658097 @default.
• W2023255442 cites W2044368552 @default.
• W2023255442 cites W2046705186 @default.
• W2023255442 cites W2051860167 @default.
• W2023255442 cites W2053085095 @default.
• W2023255442 cites W2074895627 @default.
• W2023255442 cites W2076150166 @default.
• W2023255442 cites W2081251225 @default.
• W2023255442 cites W2093531337 @default.
• W2023255442 cites W2120824167 @default.
• W2023255442 cites W2122085123 @default.
• W2023255442 cites W2136406052 @default.
• W2023255442 cites W2137669059 @default.
• W2023255442 cites W2152727843 @default.
• W2023255442 cites W2162310837 @default.
• W2023255442 cites W2301404923 @default.
• W2023255442 cites W2595176684 @default.
• W2023255442 cites W37005 @default.
• W2023255442 cites W4211223857 @default.
• W2023255442 cites W4245200085 @default.
• W2023255442 doi "https://doi.org/10.1016/j.baga.2012.06.007" @default.
• W2023255442 hasPublicationYear "2012" @default.
• W2023255442 type Work @default.
• W2023255442 sameAs 2023255442 @default.
• W2023255442 citedByCount "3" @default.
• W2023255442 countsByYear W20232554422014 @default.
• W2023255442 countsByYear W20232554422016 @default.
• W2023255442 countsByYear W20232554422020 @default.
• W2023255442 crossrefType "journal-article" @default.
• W2023255442 hasAuthorship W2023255442A5039229902 @default.
• W2023255442 hasAuthorship W2023255442A5069978273 @default.
• W2023255442 hasConcept C126322002 @default.
• W2023255442 hasConcept C181199279 @default.
• W2023255442 hasConcept C185592680 @default.
• W2023255442 hasConcept C2776024655 @default.
• W2023255442 hasConcept C2776134090 @default.
• W2023255442 hasConcept C2779134260 @default.
• W2023255442 hasConcept C2779734285 @default.
• W2023255442 hasConcept C2781249495 @default.
• W2023255442 hasConcept C3018987647 @default.
• W2023255442 hasConcept C39398028 @default.
• W2023255442 hasConcept C55493867 @default.
• W2023255442 hasConcept C71924100 @default.
• W2023255442 hasConceptScore W2023255442C126322002 @default.
• W2023255442 hasConceptScore W2023255442C181199279 @default.
• W2023255442 hasConceptScore W2023255442C185592680 @default.
• W2023255442 hasConceptScore W2023255442C2776024655 @default.
• W2023255442 hasConceptScore W2023255442C2776134090 @default.
• W2023255442 hasConceptScore W2023255442C2779134260 @default.
• W2023255442 hasConceptScore W2023255442C2779734285 @default.
• W2023255442 hasConceptScore W2023255442C2781249495 @default.
• W2023255442 hasConceptScore W2023255442C3018987647 @default.
• W2023255442 hasConceptScore W2023255442C39398028 @default.
• W2023255442 hasConceptScore W2023255442C55493867 @default.
• W2023255442 hasConceptScore W2023255442C71924100 @default.
• W2023255442 hasLocation W20232554421 @default.
• W2023255442 hasOpenAccess W2023255442 @default.
• W2023255442 hasPrimaryLocation W20232554421 @default.
• W2023255442 hasRelatedWork W1970192609 @default.
• W2023255442 hasRelatedWork W2026893785 @default.
• W2023255442 hasRelatedWork W2052982480 @default.
• W2023255442 hasRelatedWork W2076125343 @default.
• W2023255442 hasRelatedWork W2108628401 @default.
• W2023255442 hasRelatedWork W2597484286 @default.
• W2023255442 hasRelatedWork W2778504359 @default.
• W2023255442 hasRelatedWork W4224121502 @default.
• W2023255442 hasRelatedWork W4368359135 @default.
• W2023255442 hasRelatedWork W67910813 @default.
• W2023255442 isParatext "false" @default.
• W2023255442 isRetracted "false" @default.
• W2023255442 magId "2023255442" @default.
• W2023255442 workType "article" @default.