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• W2023255639 abstract "<i>Background/Aims:</i> Morphine is known to inhibit cholinergic contractions of the guinea pig small intestine. This has been compared to the human small intestinal innervated longitudinal muscle in the current study. <i>Methods:</i> Cholinergic primary contractions of human small intestinal longitudinal strips were evoked by electrical field stimulation (EFS; 0.5– 5 Hz in the presence of purinergic and nitrergic blockers or 5 Hz without pretreatment) and recorded isotonically in organ bath experiments. Guinea pig small intestinal segments were also studied. <i>Results and Conclusion:</i> Neurogenic cholinergic contractions of human preparations were unaffected by morphine (1, 2 or 10 µmol/l). Longitudinal contractions of the guinea pig ileum were concentration-dependently suppressed by morphine (0.1–10 µmol/l). It is concluded that myenteric neurons supplying the longitudinal muscle of the human small intestine are much less sensitive to morphine than those of the guinea pig." @default.
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• W2023255639 date "2010-01-01" @default.
• W2023255639 modified "2023-10-18" @default.
• W2023255639 title "Unexpected Insensitivity of the Cholinergic Motor Responses to Morphine in the Human Small Intestine" @default.
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• W2023255639 doi "https://doi.org/10.1159/000316637" @default.
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