FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023256244> ?p ?o ?g. }

• W2023256244 endingPage "153" @default.
• W2023256244 startingPage "143" @default.
• W2023256244 abstract "Excessive activation of AMPA receptor has been implicated in motor neuron degeneration in amyotrophic lateral sclerosis (ALS). However, it is not clear why motor neurons are preferentially sensitive to AMPA receptor mediated excessive [Ca(2+)]i rise and excitotoxicity. In the present study we examined whether palmitoylation regulates Ca(2+) permeability of AMPA receptor and excitotoxicity in cultured spinal cord neurons. We adapted chronic 2-bromopalmitate (2-BrP) treatment to achieve depalmitoylation and examined its effect on the cytotoxicity in spinal cord neurons exposed to AMPA. The change in AMPA induced signaling and cytotoxicity in motor neurons and other spinal neurons under identical conditions of exposure to AMPA was studied. 2-BrP treatment inhibited AMPA induced rise in [Ca(2+)]i and cytotoxicity in both types of neurons but the degree of inhibition was significantly higher in motor neurons as compared to other spinal neurons. The AMPA induced [Na(+)]i rise was moderately affected in both type of neurons on depalmitoylation. Depalmitoylation reduced the expression levels of AMPA receptor subunits (GluR1 and GluR2) and also PSD-95 but stargazin levels remained unaffected. Our results demonstrate that 2-BrP attenuates AMPA receptor activated Ca(2+) signaling and cytotoxicity preferentially in motor neurons and suggest that AMPA receptor modulation by depalmitoylation could play a significant role in preventing motor neuron degeneration." @default.
• W2023256244 created "2016-06-24" @default.
• W2023256244 creator A5013377125 @default.
• W2023256244 creator A5054796141 @default.
• W2023256244 creator A5062167362 @default.
• W2023256244 creator A5062314760 @default.
• W2023256244 creator A5079347417 @default.
• W2023256244 creator A5090056491 @default.
• W2023256244 date "2013-09-01" @default.
• W2023256244 modified "2023-09-23" @default.
• W2023256244 title "Depalmitoylation preferentially downregulates AMPA induced Ca2+ signaling and neurotoxicity in motor neurons" @default.
• W2023256244 cites W1540069135 @default.
• W2023256244 cites W1554983328 @default.
• W2023256244 cites W1638297412 @default.
• W2023256244 cites W1674757660 @default.
• W2023256244 cites W1810764863 @default.
• W2023256244 cites W1903544737 @default.
• W2023256244 cites W1964840357 @default.
• W2023256244 cites W1974741503 @default.
• W2023256244 cites W1975682391 @default.
• W2023256244 cites W1985768880 @default.
• W2023256244 cites W1988884099 @default.
• W2023256244 cites W1989154421 @default.
• W2023256244 cites W1989938166 @default.
• W2023256244 cites W1996208391 @default.
• W2023256244 cites W2005461829 @default.
• W2023256244 cites W2011861512 @default.
• W2023256244 cites W2014611177 @default.
• W2023256244 cites W2018458016 @default.
• W2023256244 cites W2020916481 @default.
• W2023256244 cites W2022669791 @default.
• W2023256244 cites W2029359382 @default.
• W2023256244 cites W2035856577 @default.
• W2023256244 cites W2048247819 @default.
• W2023256244 cites W2051710103 @default.
• W2023256244 cites W2066358338 @default.
• W2023256244 cites W2069863147 @default.
• W2023256244 cites W2075511792 @default.
• W2023256244 cites W2076279015 @default.
• W2023256244 cites W2089663252 @default.
• W2023256244 cites W2094052782 @default.
• W2023256244 cites W2094258097 @default.
• W2023256244 cites W2099707218 @default.
• W2023256244 cites W2126133831 @default.
• W2023256244 cites W2138136052 @default.
• W2023256244 cites W2139388209 @default.
• W2023256244 cites W2147542138 @default.
• W2023256244 cites W2171721487 @default.
• W2023256244 doi "https://doi.org/10.1016/j.brainres.2013.06.039" @default.
• W2023256244 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23850769" @default.
• W2023256244 hasPublicationYear "2013" @default.
• W2023256244 type Work @default.
• W2023256244 sameAs 2023256244 @default.
• W2023256244 citedByCount "4" @default.
• W2023256244 countsByYear W20232562442018 @default.
• W2023256244 countsByYear W20232562442019 @default.
• W2023256244 countsByYear W20232562442021 @default.
• W2023256244 crossrefType "journal-article" @default.
• W2023256244 hasAuthorship W2023256244A5013377125 @default.
• W2023256244 hasAuthorship W2023256244A5054796141 @default.
• W2023256244 hasAuthorship W2023256244A5062167362 @default.
• W2023256244 hasAuthorship W2023256244A5062314760 @default.
• W2023256244 hasAuthorship W2023256244A5079347417 @default.
• W2023256244 hasAuthorship W2023256244A5090056491 @default.
• W2023256244 hasConcept C160268369 @default.
• W2023256244 hasConcept C169760540 @default.
• W2023256244 hasConcept C170493617 @default.
• W2023256244 hasConcept C2776752467 @default.
• W2023256244 hasConcept C2780775167 @default.
• W2023256244 hasConcept C2781012912 @default.
• W2023256244 hasConcept C55493867 @default.
• W2023256244 hasConcept C61174792 @default.
• W2023256244 hasConcept C86803240 @default.
• W2023256244 hasConcept C95444343 @default.
• W2023256244 hasConceptScore W2023256244C160268369 @default.
• W2023256244 hasConceptScore W2023256244C169760540 @default.
• W2023256244 hasConceptScore W2023256244C170493617 @default.
• W2023256244 hasConceptScore W2023256244C2776752467 @default.
• W2023256244 hasConceptScore W2023256244C2780775167 @default.
• W2023256244 hasConceptScore W2023256244C2781012912 @default.
• W2023256244 hasConceptScore W2023256244C55493867 @default.
• W2023256244 hasConceptScore W2023256244C61174792 @default.
• W2023256244 hasConceptScore W2023256244C86803240 @default.
• W2023256244 hasConceptScore W2023256244C95444343 @default.
• W2023256244 hasFunder F4320320721 @default.
• W2023256244 hasLocation W20232562441 @default.
• W2023256244 hasLocation W20232562442 @default.
• W2023256244 hasOpenAccess W2023256244 @default.
• W2023256244 hasPrimaryLocation W20232562441 @default.
• W2023256244 hasRelatedWork W169201889 @default.
• W2023256244 hasRelatedWork W1975662652 @default.
• W2023256244 hasRelatedWork W1975682391 @default.
• W2023256244 hasRelatedWork W1990201126 @default.
• W2023256244 hasRelatedWork W1997045117 @default.
• W2023256244 hasRelatedWork W2002928184 @default.
• W2023256244 hasRelatedWork W2066557327 @default.
• W2023256244 hasRelatedWork W2747552812 @default.
• W2023256244 hasRelatedWork W4206183791 @default.

• next