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• W2023256937 abstract "The risk posed by immunization against influenza in asthmatic children is unclear, as is the risk posed by actual infection with influenza virus. The peak expiratory flow rate (PEFR) was measured twice daily in 79 asthmatic children following immunization with bivalent (A/Port Chalmers/1/73 and B/Hong Kong/5/72) vaccine containing killed influenza virus. A transient decrease in PEFR was most apparent at 48 hours (P < 0.05), coinciding with a significant increase in the need for treatments with nebulization of a bronchodilator drug (P < 0.01). When examined at 24 hours, the majority of subjects (49) had a decreased PEFR, but clinical exacerbation of severe asthma was rare. Protection afforded by immunization against infection with influenza virus was examined in 55 immunized and 38 control patients during a subsequent epidemic; hospitalization for influenza-like illness (P < 0.01) and for influenza-like illness accompanied by asthma (P < 0.05) was diminished. Hospitalization for asthma alone was not affected. Thus, immunization against influenza may be accompanied by transient reversible impairment of the flow of air in many asthmatic children, but morbidity from subsequent infection with influenza virus is significantly reduced, justifying continuation of the practice of prophylactic immunization against influenza. The risk posed by immunization against influenza in asthmatic children is unclear, as is the risk posed by actual infection with influenza virus. The peak expiratory flow rate (PEFR) was measured twice daily in 79 asthmatic children following immunization with bivalent (A/Port Chalmers/1/73 and B/Hong Kong/5/72) vaccine containing killed influenza virus. A transient decrease in PEFR was most apparent at 48 hours (P < 0.05), coinciding with a significant increase in the need for treatments with nebulization of a bronchodilator drug (P < 0.01). When examined at 24 hours, the majority of subjects (49) had a decreased PEFR, but clinical exacerbation of severe asthma was rare. Protection afforded by immunization against infection with influenza virus was examined in 55 immunized and 38 control patients during a subsequent epidemic; hospitalization for influenza-like illness (P < 0.01) and for influenza-like illness accompanied by asthma (P < 0.05) was diminished. Hospitalization for asthma alone was not affected. Thus, immunization against influenza may be accompanied by transient reversible impairment of the flow of air in many asthmatic children, but morbidity from subsequent infection with influenza virus is significantly reduced, justifying continuation of the practice of prophylactic immunization against influenza." @default.
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• W2023256937 date "1978-02-01" @default.
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• W2023256937 title "Immunization with Killed Influenza Virus in Children with Chronic Asthma" @default.
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• W2023256937 doi "https://doi.org/10.1378/chest.73.2.140" @default.
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