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• W2023258154 abstract "Summary The vitamin E requirement in rats during selenium (Se) deficiency was investigated. Compared with other vitamin E depletion studies in rats, a simultaneous Se deficiency shortened the time of onset of vitamin E deficiency symptoms, including the decline in body weight gain. The minimum total requirement of vitamin E for survival was found to be about 7 mg DL-α-tocopheryl acetate/kg feed when the selenium content of the diet was only 6.6 μg/kg diet and the vitamin E/PUFA ratio was 0.45. Histopathological changes, including centrolobular and massive hepatic necrosis, renal cortical necrosis, and skeletal muscle degeneration, the both last mentioned with simultaneous calcifications, were observed only in the rats of the unsupplemented group, fed the basal vitamin E — selenium-deficient diet. Blood haemoglobin was not influenced by dietary vitamin E and/or selenium contents. Se deficiency was followed by a subsequent decrease in Se-dependent glutathione peroxidase (Se-GSH-Px) in plasma and erythrocytes. This was compensated by a simultaneous increase in Se-independent glutathione peroxidase (Non-Se-GSH-Px) activity. The Non-Se-GSH-Px activities in plasma and erythrocytes were more than doubled during the experimental period of eight weeks. The Non-Se-GSH-Px and Se-GSH-Px activities were found to be independent of the level of vitamin E supplementation. It is concluded that the compensatory induction of Non-Se-GSH-Px activity in rats during selenium deficiency could at least be partly responsible for the relatively low requirement of the rat for vitamin E. Zusammenfassung Vitamin E-Bedarf der wachsenden Ratte bei Selenmangel unter besonderer Berücksichtigung der selenabhängigen und selenunabhängigen Glutathionperoxidase Bei wachsenden Ratten wurde der Vitamin E-Bedarf während eíner Selenmangeldiät untersucht. Im Vergleich zu anderen Vitamin E-Depletionstests bei Ratten verkürzte der Selenmangel den zeitlichen Abstand bis zum Auftreten von Vitamin E-Mangelsymptomen, einschließlich Gewichtsabnahmen. Der minimale Bedarf an Vitamin E betrug etwa 7 mg DL-α-Tokopherolacetat/kg Futter, wenn der Selengehalt der Diät lediglich 6,6 μg/kg Futter betrug, bei einem Vitamin E/PUFA-Verhältnis von 0,45. Histopathologische Veränderungen, wie massive zentrolobuläre Lebernekrosen, Nierenrinder-nekrosen und Skelettmuskeldegeneration, die beiden letzteren gleichzeitig mit Kalzifikationen, wurden nur bei Ratten der nichtsupplementierten Gruppe, welche die basale Vitamin E-Mangeldiät erhielt, beobachtet. Der Hämoglobingehalt im Blut wurde weder durch den Vitamin E- noch den Selengehalt der Diät beeinflußt." @default.
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• W2023258154 date "1986-02-12" @default.
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• W2023258154 title "Vitamin E Requirement of the Growing Rat During Selenium Deficiency with Special Reference to Selenium Dependent - and Selenium Independent Glutathione Peroxidase" @default.
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• W2023258154 doi "https://doi.org/10.1111/j.1439-0442.1986.tb00533.x" @default.
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