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• W2023258786 endingPage "58" @default.
• W2023258786 startingPage "55" @default.
• W2023258786 abstract "Metallothionein (MT), a low molecular weight, cysteine‐rich metal binding protein, has been associated with cytoprotection from heavy metals and cellular oxidants. As MT has the ability to scavenge hydroxyl radicals, MT may control intracellular redox status. In the present study, we examined whether MT regulates the activity of nuclear factor‐κB (NF‐κB), which is one of the redox‐regulated transcription factors, using the MT null embryonic cell lines established from MT null mice. We first found that tumor necrosis factor (TNF)‐induced activation of the binding of NF‐κB protein to DNA in wild type MT+/+ cells was lower than that in MT−/− cells. The NF‐κB activation in MT‐expressing cells established from MT−/− cells by the transfection of mouse MT‐I gene was also significantly lower than that in MT−/− cells. In addition, transfection of the MT gene inhibited TNF‐induced IκB degradation and suppressed NF‐κB‐dependent gene expression induced by TNF. These results demonstrate that MT may function as a negative regulator of NF‐κB activity." @default.
• W2023258786 created "2016-06-24" @default.
• W2023258786 creator A5027119057 @default.
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• W2023258786 date "1999-07-15" @default.
• W2023258786 modified "2023-10-17" @default.
• W2023258786 title "Regulatory role of metallothionein in NF‐κB activation" @default.
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• W2023258786 doi "https://doi.org/10.1016/s0014-5793(99)00839-x" @default.
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