FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023258833> ?p ?o ?g. }

• W2023258833 endingPage "6055" @default.
• W2023258833 startingPage "6044" @default.
• W2023258833 abstract "Mutated in colorectal cancer (MCC) was originally identified as a candidate gene for familial adenomatous polyposis (FAP) but further study identified adenomatous polyposis coli (APC) as responsible for FAP and the physiologic/pathologic roles of MCC remained poorly understood. Recently, MCC promoter methylation was discovered as a frequent early event in a distinct subset of precursor lesions and colorectal cancer (CRC) associated with the serrated CRC pathway. Here we provide the first evidence of the biological significance of MCC loss in CRC and the molecular pathways involved. We show MCC expression is dramatically decreased in many CRC cell lines and the distinct subset of sporadic CRC characterized by the CpG island methylator phenotype and BRAFV600E mutation due to promoter methylation as reported previously. Importantly, we find MCC interacts with β-catenin and that reexpression of MCC in CRC cells specifically inhibits Wnt signaling, β-catenin/T-cell factor/lymphoid-enhancer factor-dependent transcription and cellular proliferation even in the presence of oncogenic mutant APC. We also show that MCC is localized in the nucleus and identify two functional nuclear localization signals. Taken together, MCC is a nuclear, β-catenin-interacting protein that can act as a potential tumor suppressor in the serrated CRC pathway by inhibiting Wnt/β-catenin signal transduction." @default.
• W2023258833 created "2016-06-24" @default.
• W2023258833 creator A5008593219 @default.
• W2023258833 creator A5012675740 @default.
• W2023258833 creator A5022375331 @default.
• W2023258833 creator A5023722140 @default.
• W2023258833 creator A5029750350 @default.
• W2023258833 creator A5032897491 @default.
• W2023258833 creator A5039079081 @default.
• W2023258833 creator A5048623341 @default.
• W2023258833 creator A5084496654 @default.
• W2023258833 date "2008-06-30" @default.
• W2023258833 modified "2023-10-17" @default.
• W2023258833 title "Mutated in colorectal cancer, a putative tumor suppressor for serrated colorectal cancer, selectively represses β-catenin-dependent transcription" @default.
• W2023258833 cites W1499561015 @default.
• W2023258833 cites W1666932156 @default.
• W2023258833 cites W1902879109 @default.
• W2023258833 cites W1975993620 @default.
• W2023258833 cites W1979349349 @default.
• W2023258833 cites W1979618971 @default.
• W2023258833 cites W1985871447 @default.
• W2023258833 cites W1993748871 @default.
• W2023258833 cites W1994465394 @default.
• W2023258833 cites W1999742139 @default.
• W2023258833 cites W2000072880 @default.
• W2023258833 cites W2011134747 @default.
• W2023258833 cites W2013837983 @default.
• W2023258833 cites W2015941534 @default.
• W2023258833 cites W2046073394 @default.
• W2023258833 cites W2049198730 @default.
• W2023258833 cites W2059813946 @default.
• W2023258833 cites W2063726851 @default.
• W2023258833 cites W2068400261 @default.
• W2023258833 cites W2074906952 @default.
• W2023258833 cites W2078576765 @default.
• W2023258833 cites W2081367726 @default.
• W2023258833 cites W2084469088 @default.
• W2023258833 cites W2092691551 @default.
• W2023258833 cites W2093033974 @default.
• W2023258833 cites W2103547637 @default.
• W2023258833 cites W2108435741 @default.
• W2023258833 cites W2110116384 @default.
• W2023258833 cites W2113359377 @default.
• W2023258833 cites W2124076790 @default.
• W2023258833 cites W2130348044 @default.
• W2023258833 cites W2154515128 @default.
• W2023258833 cites W2169903102 @default.
• W2023258833 cites W4206257968 @default.
• W2023258833 cites W52606055 @default.
• W2023258833 doi "https://doi.org/10.1038/onc.2008.204" @default.
• W2023258833 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2574581" @default.
• W2023258833 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18591935" @default.
• W2023258833 hasPublicationYear "2008" @default.
• W2023258833 type Work @default.
• W2023258833 sameAs 2023258833 @default.
• W2023258833 citedByCount "73" @default.
• W2023258833 countsByYear W20232588332012 @default.
• W2023258833 countsByYear W20232588332013 @default.
• W2023258833 countsByYear W20232588332014 @default.
• W2023258833 countsByYear W20232588332015 @default.
• W2023258833 countsByYear W20232588332016 @default.
• W2023258833 countsByYear W20232588332017 @default.
• W2023258833 countsByYear W20232588332018 @default.
• W2023258833 countsByYear W20232588332019 @default.
• W2023258833 countsByYear W20232588332020 @default.
• W2023258833 countsByYear W20232588332021 @default.
• W2023258833 countsByYear W20232588332022 @default.
• W2023258833 crossrefType "journal-article" @default.
• W2023258833 hasAuthorship W2023258833A5008593219 @default.
• W2023258833 hasAuthorship W2023258833A5012675740 @default.
• W2023258833 hasAuthorship W2023258833A5022375331 @default.
• W2023258833 hasAuthorship W2023258833A5023722140 @default.
• W2023258833 hasAuthorship W2023258833A5029750350 @default.
• W2023258833 hasAuthorship W2023258833A5032897491 @default.
• W2023258833 hasAuthorship W2023258833A5039079081 @default.
• W2023258833 hasAuthorship W2023258833A5048623341 @default.
• W2023258833 hasAuthorship W2023258833A5084496654 @default.
• W2023258833 hasBestOaLocation W20232588332 @default.
• W2023258833 hasConcept C104317684 @default.
• W2023258833 hasConcept C111669997 @default.
• W2023258833 hasConcept C121608353 @default.
• W2023258833 hasConcept C137620995 @default.
• W2023258833 hasConcept C150194340 @default.
• W2023258833 hasConcept C190727270 @default.
• W2023258833 hasConcept C2778237340 @default.
• W2023258833 hasConcept C2780814781 @default.
• W2023258833 hasConcept C30145163 @default.
• W2023258833 hasConcept C502942594 @default.
• W2023258833 hasConcept C526805850 @default.
• W2023258833 hasConcept C54355233 @default.
• W2023258833 hasConcept C555283112 @default.
• W2023258833 hasConcept C62478195 @default.
• W2023258833 hasConcept C86339819 @default.
• W2023258833 hasConcept C86803240 @default.
• W2023258833 hasConceptScore W2023258833C104317684 @default.
• W2023258833 hasConceptScore W2023258833C111669997 @default.
• W2023258833 hasConceptScore W2023258833C121608353 @default.
• W2023258833 hasConceptScore W2023258833C137620995 @default.

• next