Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023259804> ?p ?o ?g. }
Showing items 1 to 92 of
92
with 100 items per page.
- W2023259804 endingPage "804" @default.
- W2023259804 startingPage "800" @default.
- W2023259804 abstract "Current therapeutic approaches to treat cancer are often hampered by the lack of specificity of the drugs used for therapy. Scavidin, a novel fusion protein expressed on cell membranes, could be utilized for targeting of therapeutic molecules. Scavidin exploits the high binding affinity between avidin and biotin and is capable of mediating endocytosis of a bound ligand. In the current study we evaluated the efficiency of biotinylated ultrasmall superparamagnetic iron oxide (USPIO) particles in Scavidin-expressing human umbilical vein endothelial cell (HUVEC) cultures in vitro as a novel receptor-targeted magnetic resonance imaging contrast agent. Biotinylated USPIO (bUSPIO) were targeted to Scavidin adenovirus-transduced HUVECs in vitro. Scavidin expressing cells were capable of binding and mediating endocytosis of the bUSPIO in vitro, which led to a significant decrease in T2 relaxation times, and a loss of signal intensity in comparison to controls. The findings were confirmed with Prussian blue staining for iron and detection of Scavidin by bound biotinylated horseradish peroxidase. Our data shows that biotinylated ligands target specifically to Scavidin-expressing HUVEC in vitro. The utilization of Scavidin gene transfer ex vivo thus constitutes a platform for potential ligand delivery via cell therapy and time-independent imaging of biologic processes. Magn Reson Med, 2006. © 2006 Wiley-Liss, Inc." @default.
- W2023259804 created "2016-06-24" @default.
- W2023259804 creator A5009878381 @default.
- W2023259804 creator A5014220812 @default.
- W2023259804 creator A5019394194 @default.
- W2023259804 creator A5027453838 @default.
- W2023259804 creator A5066733166 @default.
- W2023259804 date "2006-01-01" @default.
- W2023259804 modified "2023-10-17" @default.
- W2023259804 title "Targeted magnetic resonance imaging of Scavidin-receptor in human umbilical vein endothelial cells in vitro" @default.
- W2023259804 cites W1999579644 @default.
- W2023259804 cites W2000970414 @default.
- W2023259804 cites W2022532948 @default.
- W2023259804 cites W2025817925 @default.
- W2023259804 cites W2053704719 @default.
- W2023259804 cites W2053706156 @default.
- W2023259804 cites W2054728198 @default.
- W2023259804 cites W2063609336 @default.
- W2023259804 cites W2112602860 @default.
- W2023259804 cites W2121045793 @default.
- W2023259804 cites W2157603347 @default.
- W2023259804 cites W2164324123 @default.
- W2023259804 cites W2335028388 @default.
- W2023259804 cites W4211027922 @default.
- W2023259804 doi "https://doi.org/10.1002/mrm.20834" @default.
- W2023259804 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16526021" @default.
- W2023259804 hasPublicationYear "2006" @default.
- W2023259804 type Work @default.
- W2023259804 sameAs 2023259804 @default.
- W2023259804 citedByCount "11" @default.
- W2023259804 countsByYear W20232598042012 @default.
- W2023259804 countsByYear W20232598042014 @default.
- W2023259804 countsByYear W20232598042016 @default.
- W2023259804 crossrefType "journal-article" @default.
- W2023259804 hasAuthorship W2023259804A5009878381 @default.
- W2023259804 hasAuthorship W2023259804A5014220812 @default.
- W2023259804 hasAuthorship W2023259804A5019394194 @default.
- W2023259804 hasAuthorship W2023259804A5027453838 @default.
- W2023259804 hasAuthorship W2023259804A5066733166 @default.
- W2023259804 hasBestOaLocation W20232598041 @default.
- W2023259804 hasConcept C12554922 @default.
- W2023259804 hasConcept C1491633281 @default.
- W2023259804 hasConcept C153911025 @default.
- W2023259804 hasConcept C176406525 @default.
- W2023259804 hasConcept C185592680 @default.
- W2023259804 hasConcept C202751555 @default.
- W2023259804 hasConcept C204628709 @default.
- W2023259804 hasConcept C2776190903 @default.
- W2023259804 hasConcept C2777411675 @default.
- W2023259804 hasConcept C2777834122 @default.
- W2023259804 hasConcept C2778204606 @default.
- W2023259804 hasConcept C28005876 @default.
- W2023259804 hasConcept C55493867 @default.
- W2023259804 hasConcept C86803240 @default.
- W2023259804 hasConcept C95444343 @default.
- W2023259804 hasConceptScore W2023259804C12554922 @default.
- W2023259804 hasConceptScore W2023259804C1491633281 @default.
- W2023259804 hasConceptScore W2023259804C153911025 @default.
- W2023259804 hasConceptScore W2023259804C176406525 @default.
- W2023259804 hasConceptScore W2023259804C185592680 @default.
- W2023259804 hasConceptScore W2023259804C202751555 @default.
- W2023259804 hasConceptScore W2023259804C204628709 @default.
- W2023259804 hasConceptScore W2023259804C2776190903 @default.
- W2023259804 hasConceptScore W2023259804C2777411675 @default.
- W2023259804 hasConceptScore W2023259804C2777834122 @default.
- W2023259804 hasConceptScore W2023259804C2778204606 @default.
- W2023259804 hasConceptScore W2023259804C28005876 @default.
- W2023259804 hasConceptScore W2023259804C55493867 @default.
- W2023259804 hasConceptScore W2023259804C86803240 @default.
- W2023259804 hasConceptScore W2023259804C95444343 @default.
- W2023259804 hasIssue "4" @default.
- W2023259804 hasLocation W20232598041 @default.
- W2023259804 hasLocation W20232598042 @default.
- W2023259804 hasOpenAccess W2023259804 @default.
- W2023259804 hasPrimaryLocation W20232598041 @default.
- W2023259804 hasRelatedWork W1503533743 @default.
- W2023259804 hasRelatedWork W1536131202 @default.
- W2023259804 hasRelatedWork W1985110858 @default.
- W2023259804 hasRelatedWork W1991127274 @default.
- W2023259804 hasRelatedWork W2026593038 @default.
- W2023259804 hasRelatedWork W2067031238 @default.
- W2023259804 hasRelatedWork W2070869769 @default.
- W2023259804 hasRelatedWork W2327149835 @default.
- W2023259804 hasRelatedWork W2952131322 @default.
- W2023259804 hasRelatedWork W4293102437 @default.
- W2023259804 hasVolume "55" @default.
- W2023259804 isParatext "false" @default.
- W2023259804 isRetracted "false" @default.
- W2023259804 magId "2023259804" @default.
- W2023259804 workType "article" @default.