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- W2023259810 abstract "Abstract Objectives In this review article, bilateral orchiectomy is compared with conventional luteinising hormone-releasing hormone (LHRH) agonists in terms of efficacy, safety, patients' perception of health, and testosterone suppression. The efficacy and safety of a new LHRH depot formulation, Eligard ® , is compared with conventional LHRH agonists. Methods A Medline search was performed in the beginning of 2006. Only fully published studies and review articles in English were included. Results Conventional LHRH agonists are not equivalent to bilateral orchiectomy in terms of testosterone suppression. They also cause a higher incidence of hot flashes as compared to bilateral orchiectomy. Patients treated with LHRH agonists seem to worry more about their disease than patients who underwent bilateral orchiectomy. Studies have shown that Eligard, a new extended-release leuprolide formulation, achieves and maintains testosterone suppression equivalent to bilateral orchiectomy. Eligard 1- and 3-mo formulations have a similar side-effect profile as other conventional LHRH agonists and induce few severe hot flashes. Conclusions Eligard is able to achieve and maintain testosterone suppression levels equal to bilateral orchiectomy." @default.
- W2023259810 created "2016-06-24" @default.
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- W2023259810 date "2006-11-01" @default.
- W2023259810 modified "2023-09-27" @default.
- W2023259810 title "Eligard®: Advantages for Optimal Testosterone Control" @default.
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- W2023259810 doi "https://doi.org/10.1016/j.eursup.2006.08.007" @default.
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