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• W2023261680 abstract "While genetically encoded Ca2+ indicators (GECIs) allow Ca2+ imaging in model organisms, the gene expression is often under the control of a single promoter that may drive expression beyond, the cell types of interest. To enable more cell-type specific targeting, GECIs can be brought under the, control of the intersecting expression from two promoters. Here, we present the splitting and, reassembly of two representative GECIs (TN-XL and GCaMP2) mediated by the split intein from Nostoc, punctiforme (NpuDnaE). While the split TN-XL biosensor offered ratiometric Ca2+ imaging, it had a, diminished Ca2+ response relative to the native TN-XL biosensor. In contrast, the split GCaMP2, biosensor retained similar Ca2+ response to the native GCaMP2. The split GCaMP2 biosensor was, further targeted to the pharyngeal muscles of Caenorhabditis elegans where Ca2+ signals from feeding C. elegans, were imaged. Thus, we envision that increased cell-type targetability of GECIs is feasible with two, complementary promoters." @default.
• W2023261680 created "2016-06-24" @default.
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• W2023261680 date "2012-01-01" @default.
• W2023261680 modified "2023-10-18" @default.
• W2023261680 title "Split-intein mediated re-assembly of genetically encoded Ca2+ indicators" @default.
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• W2023261680 doi "https://doi.org/10.1016/j.ceca.2011.10.006" @default.
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