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• W2023262761 abstract "This study examined the morphological and compositional structure of bone-implant interfaces after in vivo implantation into the tibias of rabbits. The implants were composed of biodegradable polyhydroxybutyrate/polyhydroxyvalerate copolymer reinforced with synthetic hydroxyapatite (HA) particles. Optical and scanning electron microscopy techniques were used, including energy-dispersive X-ray analysis. The interface was found to be morphologically, biologically and chemically active throughout the period of study. There was a strong tendency to rebuild the bone structure at the interface after implantation, independent of the composition of the implant, but direct bone bonding with the implant depended on the bioactive nature of the interface, as represented by the HA particles. At all implantation times, lamellar bone formed at the interface and replaced degrading polymer matrix, while engulfing HA filler particles. In regions about 50-100 from the interface, the bone region displayed an osteon organization. Osteoblasts and osteocytes were identified throughout the interface region. The thickness of the newly formed bone significantly increased over the period of the experiment from about 130 microm at 1 month to about 770 microm at 6 months. Materials that behave in this manner may be useful in some bone replacement therapies." @default.
• W2023262761 created "2016-06-24" @default.
• W2023262761 creator A5003090423 @default.
• W2023262761 creator A5062718990 @default.
• W2023262761 date "2003-07-29" @default.
• W2023262761 modified "2023-10-16" @default.
• W2023262761 title "In vivo response to HA-polyhydroxybutyrate/polyhydroxyvalerate composite" @default.
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• W2023262761 doi "https://doi.org/10.1046/j.1365-2818.2003.01204.x" @default.
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