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- W2023265126 abstract "The effects of denervation of central noradrenergic system on the interpartner relationships of adult cats were examined in a predatory test in the competitive situation for paired animals. Direct administration of the noradrenaline neurotoxin, N-2-chloroethyl-N-ethyl-2-bromobenzylamine (DSP-4 12 μg) into the medial forebrain bundle (MFB) of submissive cats changed previously established dominant–submissive relationship. Biochemical analysis demonstrated a significant reduction of noradrenaline (NA) concentration in the hypothalamus (AH), amygdala (AM), hippocampus (HC), and frontal cortex (CTX), and elevation of NA content in the midbrain central gray matter (CG) in MFB-lesioned cats. Simultaneously, DSP-4–induced lesions exerted significant decrease of 3-methoxy-4-hydroxyphenylethylene glycol (MHPG) content in AH, CG, HC and CTX, and increased GABA level in AH, CG, AM, and HC. These results suggest that a coincident decrease of NA metabolism and increase of GABA metabolism led to fear drive reduction." @default.
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- W2023265126 date "1998-06-01" @default.
- W2023265126 modified "2023-09-27" @default.
- W2023265126 title "Social Interactions, Brain Monoamines, and GABA Alterations in MFB-Lesioned Cats" @default.
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- W2023265126 doi "https://doi.org/10.1016/s0091-3057(98)00004-5" @default.
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