Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023265659> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W2023265659 endingPage "2028" @default.
- W2023265659 startingPage "2026" @default.
- W2023265659 abstract "The results of cytostatic therapy in metastatic melanoma are very disappointing. In phase II studies with high-dose cisplatin regimens, a remarkably high response rate was observed. In a phase I study with a short course of weekly cisplatin, combined with oral etoposide, we were able to reach, in most patients, a cisplatin dose intensity of 60 mg/m2/week. We performed a phase II study with this schedule in metastatic malignant melanoma. 15 consecutive patients were entered in the study. Treatment consisted of cisplatin 70 mg/m2 on days 1, 8, 15 and days 29, 36, 43 combined with oral etoposide 50 mg daily, days 1–15 and days 29–43. Patients with a response or stable disease continued treatment with oral etoposide 50 mg/m2 daily, days 1–21 every 4 weeks. All patients were evaluable for response and toxicity. The majority of the patients received six cycles of cisplatin with the planned cisplatin dose intensity of 60 mg/m2/week. A partial response was observed in 2 patients (13%; 95% confidence interval (CI) 2–44%) of, respectively, 22 and 12 weeks; stable disease was observed in 6 patients. Toxicity consisted mainly of alopecia and bone marrow suppression. 4 patients had tinnitus, one patient had neurotoxicity grade 1. The regimen studied has only limited activity in metastatic melanoma in spite of the high-dose intensity of cisplatin reached with this schedule." @default.
- W2023265659 created "2016-06-24" @default.
- W2023265659 creator A5000418012 @default.
- W2023265659 creator A5011819733 @default.
- W2023265659 creator A5037696756 @default.
- W2023265659 creator A5043168056 @default.
- W2023265659 creator A5045167907 @default.
- W2023265659 creator A5055323618 @default.
- W2023265659 creator A5067526861 @default.
- W2023265659 creator A5090377433 @default.
- W2023265659 date "1996-10-01" @default.
- W2023265659 modified "2023-09-25" @default.
- W2023265659 title "Phase II study of a short course of weekly high-dose cisplatin combined with long-term oral etoposide in metastatic malignant melanoma" @default.
- W2023265659 cites W184247245 @default.
- W2023265659 cites W1961069543 @default.
- W2023265659 cites W1973089244 @default.
- W2023265659 cites W1977891080 @default.
- W2023265659 cites W1998020757 @default.
- W2023265659 cites W2006151375 @default.
- W2023265659 cites W2044675217 @default.
- W2023265659 cites W2063392612 @default.
- W2023265659 cites W2066805950 @default.
- W2023265659 cites W2252830758 @default.
- W2023265659 cites W2306856286 @default.
- W2023265659 cites W2399255134 @default.
- W2023265659 cites W2407220982 @default.
- W2023265659 cites W2414499252 @default.
- W2023265659 cites W2415373016 @default.
- W2023265659 cites W2421021061 @default.
- W2023265659 doi "https://doi.org/10.1016/0959-8049(96)00187-6" @default.
- W2023265659 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8943692" @default.
- W2023265659 hasPublicationYear "1996" @default.
- W2023265659 type Work @default.
- W2023265659 sameAs 2023265659 @default.
- W2023265659 citedByCount "6" @default.
- W2023265659 countsByYear W20232656592012 @default.
- W2023265659 crossrefType "journal-article" @default.
- W2023265659 hasAuthorship W2023265659A5000418012 @default.
- W2023265659 hasAuthorship W2023265659A5011819733 @default.
- W2023265659 hasAuthorship W2023265659A5037696756 @default.
- W2023265659 hasAuthorship W2023265659A5043168056 @default.
- W2023265659 hasAuthorship W2023265659A5045167907 @default.
- W2023265659 hasAuthorship W2023265659A5055323618 @default.
- W2023265659 hasAuthorship W2023265659A5067526861 @default.
- W2023265659 hasAuthorship W2023265659A5090377433 @default.
- W2023265659 hasBestOaLocation W20232656592 @default.
- W2023265659 hasConcept C126322002 @default.
- W2023265659 hasConcept C126894567 @default.
- W2023265659 hasConcept C141071460 @default.
- W2023265659 hasConcept C2776694085 @default.
- W2023265659 hasConcept C2777658100 @default.
- W2023265659 hasConcept C2778119113 @default.
- W2023265659 hasConcept C2778239845 @default.
- W2023265659 hasConcept C2781413609 @default.
- W2023265659 hasConcept C29730261 @default.
- W2023265659 hasConcept C31760486 @default.
- W2023265659 hasConcept C502942594 @default.
- W2023265659 hasConcept C71924100 @default.
- W2023265659 hasConcept C90924648 @default.
- W2023265659 hasConceptScore W2023265659C126322002 @default.
- W2023265659 hasConceptScore W2023265659C126894567 @default.
- W2023265659 hasConceptScore W2023265659C141071460 @default.
- W2023265659 hasConceptScore W2023265659C2776694085 @default.
- W2023265659 hasConceptScore W2023265659C2777658100 @default.
- W2023265659 hasConceptScore W2023265659C2778119113 @default.
- W2023265659 hasConceptScore W2023265659C2778239845 @default.
- W2023265659 hasConceptScore W2023265659C2781413609 @default.
- W2023265659 hasConceptScore W2023265659C29730261 @default.
- W2023265659 hasConceptScore W2023265659C31760486 @default.
- W2023265659 hasConceptScore W2023265659C502942594 @default.
- W2023265659 hasConceptScore W2023265659C71924100 @default.
- W2023265659 hasConceptScore W2023265659C90924648 @default.
- W2023265659 hasIssue "11" @default.
- W2023265659 hasLocation W20232656591 @default.
- W2023265659 hasLocation W20232656592 @default.
- W2023265659 hasLocation W20232656593 @default.
- W2023265659 hasOpenAccess W2023265659 @default.
- W2023265659 hasPrimaryLocation W20232656591 @default.
- W2023265659 hasRelatedWork W1996085747 @default.
- W2023265659 hasRelatedWork W2021093326 @default.
- W2023265659 hasRelatedWork W2085562186 @default.
- W2023265659 hasRelatedWork W2086004237 @default.
- W2023265659 hasRelatedWork W2324380568 @default.
- W2023265659 hasRelatedWork W2402653143 @default.
- W2023265659 hasRelatedWork W2407433470 @default.
- W2023265659 hasRelatedWork W2417697013 @default.
- W2023265659 hasRelatedWork W2767052226 @default.
- W2023265659 hasRelatedWork W4238979556 @default.
- W2023265659 hasVolume "32" @default.
- W2023265659 isParatext "false" @default.
- W2023265659 isRetracted "false" @default.
- W2023265659 magId "2023265659" @default.
- W2023265659 workType "article" @default.