Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023265964> ?p ?o ?g. }
- W2023265964 endingPage "245" @default.
- W2023265964 startingPage "232" @default.
- W2023265964 abstract "Protein modification with ubiquitin chains is an essential signaling event catalyzed by E3 ubiquitin ligases. Most human E3s contain a signature RING domain that recruits a ubiquitin-charged E2 and a separate domain for substrate recognition. How RING-E3s can build polymeric ubiquitin chains while binding substrates and E2s at defined interfaces remains poorly understood. Here, we show that the RING-E3 APC/C catalyzes chain elongation by strongly increasing the affinity of its E2 for the distal acceptor ubiquitin in a growing conjugate. This function of the APC/C requires its coactivator as well as conserved residues of the E2 and ubiquitin. APC/C's ability to track the tip of an emerging conjugate is required for APC/C-substrate degradation and accurate cell division. Our results suggest that RING-E3s tether the distal ubiquitin of a growing chain in proximity to the active site of their E2s, allowing them to assemble polymeric conjugates without altering their binding to substrate or E2." @default.
- W2023265964 created "2016-06-24" @default.
- W2023265964 creator A5014741527 @default.
- W2023265964 creator A5016949741 @default.
- W2023265964 creator A5041715320 @default.
- W2023265964 creator A5078930162 @default.
- W2023265964 creator A5087193889 @default.
- W2023265964 date "2014-10-01" @default.
- W2023265964 modified "2023-10-17" @default.
- W2023265964 title "Ubiquitin Chain Elongation Requires E3-Dependent Tracking of the Emerging Conjugate" @default.
- W2023265964 cites W1964909962 @default.
- W2023265964 cites W1969236463 @default.
- W2023265964 cites W1969616198 @default.
- W2023265964 cites W1970554372 @default.
- W2023265964 cites W1978850887 @default.
- W2023265964 cites W1980487829 @default.
- W2023265964 cites W1980766960 @default.
- W2023265964 cites W1982004004 @default.
- W2023265964 cites W1984309491 @default.
- W2023265964 cites W1986429623 @default.
- W2023265964 cites W1991258715 @default.
- W2023265964 cites W1994751787 @default.
- W2023265964 cites W1996656575 @default.
- W2023265964 cites W2001701156 @default.
- W2023265964 cites W2007853809 @default.
- W2023265964 cites W2008174897 @default.
- W2023265964 cites W2015740282 @default.
- W2023265964 cites W2016236499 @default.
- W2023265964 cites W2020042573 @default.
- W2023265964 cites W2028157992 @default.
- W2023265964 cites W2029158215 @default.
- W2023265964 cites W2030770436 @default.
- W2023265964 cites W2036806530 @default.
- W2023265964 cites W2037533459 @default.
- W2023265964 cites W2039778506 @default.
- W2023265964 cites W2040614735 @default.
- W2023265964 cites W2041517382 @default.
- W2023265964 cites W2041652145 @default.
- W2023265964 cites W2052256388 @default.
- W2023265964 cites W2058078756 @default.
- W2023265964 cites W2058788882 @default.
- W2023265964 cites W2061050157 @default.
- W2023265964 cites W2063759666 @default.
- W2023265964 cites W2072915192 @default.
- W2023265964 cites W2075110858 @default.
- W2023265964 cites W2078870259 @default.
- W2023265964 cites W2083690210 @default.
- W2023265964 cites W2098964644 @default.
- W2023265964 cites W2108498800 @default.
- W2023265964 cites W2114517583 @default.
- W2023265964 cites W2131575598 @default.
- W2023265964 cites W2144114582 @default.
- W2023265964 cites W2145096632 @default.
- W2023265964 cites W2147542927 @default.
- W2023265964 cites W2147917253 @default.
- W2023265964 cites W2159426839 @default.
- W2023265964 cites W2167395885 @default.
- W2023265964 cites W2171018097 @default.
- W2023265964 doi "https://doi.org/10.1016/j.molcel.2014.09.010" @default.
- W2023265964 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25306918" @default.
- W2023265964 hasPublicationYear "2014" @default.
- W2023265964 type Work @default.
- W2023265964 sameAs 2023265964 @default.
- W2023265964 citedByCount "66" @default.
- W2023265964 countsByYear W20232659642014 @default.
- W2023265964 countsByYear W20232659642015 @default.
- W2023265964 countsByYear W20232659642016 @default.
- W2023265964 countsByYear W20232659642017 @default.
- W2023265964 countsByYear W20232659642018 @default.
- W2023265964 countsByYear W20232659642019 @default.
- W2023265964 countsByYear W20232659642020 @default.
- W2023265964 countsByYear W20232659642021 @default.
- W2023265964 countsByYear W20232659642022 @default.
- W2023265964 countsByYear W20232659642023 @default.
- W2023265964 crossrefType "journal-article" @default.
- W2023265964 hasAuthorship W2023265964A5014741527 @default.
- W2023265964 hasAuthorship W2023265964A5016949741 @default.
- W2023265964 hasAuthorship W2023265964A5041715320 @default.
- W2023265964 hasAuthorship W2023265964A5078930162 @default.
- W2023265964 hasAuthorship W2023265964A5087193889 @default.
- W2023265964 hasBestOaLocation W20232659641 @default.
- W2023265964 hasConcept C102658986 @default.
- W2023265964 hasConcept C104317684 @default.
- W2023265964 hasConcept C112950240 @default.
- W2023265964 hasConcept C121332964 @default.
- W2023265964 hasConcept C12554922 @default.
- W2023265964 hasConcept C1276947 @default.
- W2023265964 hasConcept C134306372 @default.
- W2023265964 hasConcept C134459356 @default.
- W2023265964 hasConcept C178790620 @default.
- W2023265964 hasConcept C182561583 @default.
- W2023265964 hasConcept C185592680 @default.
- W2023265964 hasConcept C191897082 @default.
- W2023265964 hasConcept C192562407 @default.
- W2023265964 hasConcept C197336794 @default.
- W2023265964 hasConcept C199185054 @default.
- W2023265964 hasConcept C25602115 @default.
- W2023265964 hasConcept C2780378348 @default.