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- W2023266169 abstract "Abstract The contamination of several commercial compounds by chlorinated dibenzo-ϱ-dioxins and the health hazards presented by certain dioxins have been well documented. In this study the relative absence of toxicity following high dosages of octachlorodibenzo-ϱ-dioxin (OCDD) in rats was confirmed. A moderate proliferation of the hepatic endoplasmic reticulum (ER) and hepatomegaly occurred. Daily administration of a radioactive analog of OCDD to rats by gastric intubation for 21 days resulted in the recovery of over 90% of the total dose in the feces as unabsorbed material. A small lipid-soluble fraction was excreted in the urine. After 21 days of administration, less than 1% of the total dose was present in the rat tissues. The liver contained the highest concentration with approximately 50% of the body load found within this organ. The radioactivity in the adipose tissue was approximately 25% that in the liver. Significant levels of radioactivity were found in the kidneys, heart, testes, skeletal muscle, skin, and serum. The greatest reservoirs of the material were liver, skin, and adipose tissue. Over 95% of the radioactivity within the liver was associated with the microsomes and was equally distributed within the rough and smooth fractions. Distribution of the detectable radioactivity within rats that subsequently received a control diet for 6 wk was confined to the liver, adipose tissue, and skin at levels approximately 20–25% that found immediately after the 21-day period of administration. The route of excretion was through the urinary system and the rate corresponded to a biological half-life of approximately 3 wk. Toxicity, hepatic alterations, percentage of absorption, body distribution, and biological half-life of OCDD are compared to those parameters of the extremely toxic tetrachlorodibenzo-ϱ-dioxin (TCDD). Microsomal localization of the compounds is postulated to result in sequestration of the material." @default.
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- W2023266169 date "1975-05-01" @default.
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- W2023266169 title "Tissue distribution and excretion of octachlorodibenzo-p-dioxin in the rat" @default.
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- W2023266169 doi "https://doi.org/10.1016/0041-008x(75)90223-9" @default.
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