FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023266954> ?p ?o ?g. }

• W2023266954 endingPage "76" @default.
• W2023266954 startingPage "69" @default.
• W2023266954 abstract "A cochlear implant can restore hearing function by electrically exciting spiral ganglion neurons (SGNs) in the deaf cochlea. However, following deafness SGNs undergo progressive degeneration ultimately leading to their death. One significant cause of SGN degeneration is the loss of neurotrophic support that is normally provided by cells within the organ of Corti (OC). The administration of exogenous neurotrophins (NTs) can protect SGNs from degeneration but the effects are short-lived once the source of NTs has been exhausted. NT gene therapy, whereby cells within the cochlea are transfected with genes enabling them to produce NTs, is one strategy for providing a cellular source of NTs that may provide long-term support for SGNs. As the SGNs normally innervate sensory cells within the OC, targeting residual OC cells for gene therapy in the deaf cochlea may provide a source of NTs for SGN protection and targeted regrowth of their peripheral fibers. However, the continual degeneration of the OC over extended periods of deafness may deplete the cellular targets for NT gene therapy and hence limit the effectiveness of this method in preventing SGN loss. This study examined the effects of deafness duration on the efficacy of NT gene therapy in preventing SGN loss in guinea pigs that were systemically deafened with aminoglycosides. Adenoviral vectors containing green fluorescent protein (GFP) with or without genes for Brain Derived Neurotrophic Factor (BDNF) and Neurotrophin-3 (NT3) were injected into the scala media (SM) compartment of cochleae that had been deafened for one, four or eight weeks prior to the viral injection. The results showed that viral transfection of cells within the SM was still possible even after severe degeneration of the OC. Supporting cells (pillar and Deiters’ cells), cells within the stria vascularis, the spiral ligament, endosteal cells lining the scala compartments and interdental cells in the spiral limbus were transfected. However, the level of transfection was remarkably lower following longer durations of deafness. There was a significant increase in SGN survival in the entire basal turn for cochleae that received NT gene therapy compared to the untreated contralateral control cochleae for the one week deaf group. In the four week deaf group significant SGN survival was observed in the lower basal turn only. There was no increase in SGN survival for the eight week deaf group in any cochlear region. These findings indicated that the efficacy of NT gene therapy diminished with increasing durations of deafness leading to reduced benefits in terms of SGN protection. Clinically, there remains a window of opportunity in which NT gene therapy can provide ongoing trophic support for SGNs." @default.
• W2023266954 created "2016-06-24" @default.
• W2023266954 creator A5018325827 @default.
• W2023266954 creator A5019048628 @default.
• W2023266954 creator A5029444867 @default.
• W2023266954 creator A5031267006 @default.
• W2023266954 creator A5035567868 @default.
• W2023266954 creator A5073883677 @default.
• W2023266954 creator A5078011681 @default.
• W2023266954 creator A5083126528 @default.
• W2023266954 creator A5083304505 @default.
• W2023266954 date "2011-08-01" @default.
• W2023266954 modified "2023-10-09" @default.
• W2023266954 title "The effect of deafness duration on neurotrophin gene therapy for spiral ganglion neuron protection" @default.
• W2023266954 cites W1557808140 @default.
• W2023266954 cites W1967426773 @default.
• W2023266954 cites W1974113951 @default.
• W2023266954 cites W1977034802 @default.
• W2023266954 cites W1988177186 @default.
• W2023266954 cites W1989099240 @default.
• W2023266954 cites W1989377502 @default.
• W2023266954 cites W1995461639 @default.
• W2023266954 cites W1996125609 @default.
• W2023266954 cites W1999633987 @default.
• W2023266954 cites W2006904223 @default.
• W2023266954 cites W2008803709 @default.
• W2023266954 cites W2019255057 @default.
• W2023266954 cites W2031730902 @default.
• W2023266954 cites W2035266661 @default.
• W2023266954 cites W2044015089 @default.
• W2023266954 cites W2046610720 @default.
• W2023266954 cites W2048142299 @default.
• W2023266954 cites W2058359348 @default.
• W2023266954 cites W2069855517 @default.
• W2023266954 cites W2070468547 @default.
• W2023266954 cites W2076669076 @default.
• W2023266954 cites W2078328650 @default.
• W2023266954 cites W2078683084 @default.
• W2023266954 cites W2079319002 @default.
• W2023266954 cites W2091448816 @default.
• W2023266954 cites W2095274746 @default.
• W2023266954 cites W2098264302 @default.
• W2023266954 cites W2098537456 @default.
• W2023266954 cites W2099181688 @default.
• W2023266954 cites W2152933007 @default.
• W2023266954 cites W2154101885 @default.
• W2023266954 cites W2158087466 @default.
• W2023266954 cites W2171161097 @default.
• W2023266954 doi "https://doi.org/10.1016/j.heares.2011.04.010" @default.
• W2023266954 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3152700" @default.
• W2023266954 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21557994" @default.
• W2023266954 hasPublicationYear "2011" @default.
• W2023266954 type Work @default.
• W2023266954 sameAs 2023266954 @default.
• W2023266954 citedByCount "53" @default.
• W2023266954 countsByYear W20232669542012 @default.
• W2023266954 countsByYear W20232669542013 @default.
• W2023266954 countsByYear W20232669542014 @default.
• W2023266954 countsByYear W20232669542015 @default.
• W2023266954 countsByYear W20232669542016 @default.
• W2023266954 countsByYear W20232669542017 @default.
• W2023266954 countsByYear W20232669542018 @default.
• W2023266954 countsByYear W20232669542019 @default.
• W2023266954 countsByYear W20232669542020 @default.
• W2023266954 countsByYear W20232669542021 @default.
• W2023266954 countsByYear W20232669542022 @default.
• W2023266954 countsByYear W20232669542023 @default.
• W2023266954 crossrefType "journal-article" @default.
• W2023266954 hasAuthorship W2023266954A5018325827 @default.
• W2023266954 hasAuthorship W2023266954A5019048628 @default.
• W2023266954 hasAuthorship W2023266954A5029444867 @default.
• W2023266954 hasAuthorship W2023266954A5031267006 @default.
• W2023266954 hasAuthorship W2023266954A5035567868 @default.
• W2023266954 hasAuthorship W2023266954A5073883677 @default.
• W2023266954 hasAuthorship W2023266954A5078011681 @default.
• W2023266954 hasAuthorship W2023266954A5083126528 @default.
• W2023266954 hasAuthorship W2023266954A5083304505 @default.
• W2023266954 hasBestOaLocation W20232669542 @default.
• W2023266954 hasConcept C104317684 @default.
• W2023266954 hasConcept C111599444 @default.
• W2023266954 hasConcept C126322002 @default.
• W2023266954 hasConcept C160539049 @default.
• W2023266954 hasConcept C169760540 @default.
• W2023266954 hasConcept C170493617 @default.
• W2023266954 hasConcept C2778500370 @default.
• W2023266954 hasConcept C2779152698 @default.
• W2023266954 hasConcept C2780130748 @default.
• W2023266954 hasConcept C2780493683 @default.
• W2023266954 hasConcept C2780659331 @default.
• W2023266954 hasConcept C54355233 @default.
• W2023266954 hasConcept C548259974 @default.
• W2023266954 hasConcept C71924100 @default.
• W2023266954 hasConcept C86803240 @default.
• W2023266954 hasConcept C92020748 @default.
• W2023266954 hasConcept C95444343 @default.
• W2023266954 hasConceptScore W2023266954C104317684 @default.
• W2023266954 hasConceptScore W2023266954C111599444 @default.
• W2023266954 hasConceptScore W2023266954C126322002 @default.

• next