FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023267769> ?p ?o ?g. }

• W2023267769 endingPage "539" @default.
• W2023267769 startingPage "532" @default.
• W2023267769 abstract "Infection of colonic epithelial cells by Shigella is associated with the type III secretion system, which serves as a molecular syringe to inject effectors into host cells. This system includes an extracellular needle used as a conduit for secreted proteins. Two of these proteins, IpaB and IpaD, dock at the needle tip to control secretion and are also involved in the insertion of a translocation pore into host cell membrane allowing effector delivery. To better understand the function of IpaD, we substituted thirteen residues conserved among homologous proteins in other bacterial species. Generated variants were tested for their ability to surface expose IpaB and IpaD, to control secretion, to insert the translocation pore, and to invade host cells. In addition to a first group of seven ipaD variants that behaved similarly to the wild-type strain, we identified a second group with mutations V314D and I319D that deregulated secretion of all effectors, but remained fully invasive. Moreover, we identified a third group with mutations Y153A, T161D, Q165L and Y276A, that exhibited increased levels of translocators secretion, pore formation, and cell entry. Altogether, our results offer a better understanding of the role of IpaD in the control of Shigella virulence." @default.
• W2023267769 created "2016-06-24" @default.
• W2023267769 creator A5058786642 @default.
• W2023267769 creator A5089723879 @default.
• W2023267769 creator A5091101919 @default.
• W2023267769 date "2014-07-01" @default.
• W2023267769 modified "2023-10-17" @default.
• W2023267769 title "Single amino acid substitutions on the needle tip protein IpaD increased Shigella virulence" @default.
• W2023267769 cites W1489736154 @default.
• W2023267769 cites W1495119128 @default.
• W2023267769 cites W1583038199 @default.
• W2023267769 cites W1961357949 @default.
• W2023267769 cites W1969120551 @default.
• W2023267769 cites W1970356669 @default.
• W2023267769 cites W1971096395 @default.
• W2023267769 cites W1973552999 @default.
• W2023267769 cites W1976406379 @default.
• W2023267769 cites W1976416185 @default.
• W2023267769 cites W1977764800 @default.
• W2023267769 cites W1985036198 @default.
• W2023267769 cites W2006635484 @default.
• W2023267769 cites W2010266614 @default.
• W2023267769 cites W2017728221 @default.
• W2023267769 cites W2018910670 @default.
• W2023267769 cites W2020755151 @default.
• W2023267769 cites W2045509621 @default.
• W2023267769 cites W2049212717 @default.
• W2023267769 cites W2054936556 @default.
• W2023267769 cites W2056446295 @default.
• W2023267769 cites W2056525859 @default.
• W2023267769 cites W2056922902 @default.
• W2023267769 cites W2063647354 @default.
• W2023267769 cites W2065169421 @default.
• W2023267769 cites W2066623867 @default.
• W2023267769 cites W2082264097 @default.
• W2023267769 cites W2084209390 @default.
• W2023267769 cites W2090334490 @default.
• W2023267769 cites W2097099366 @default.
• W2023267769 cites W2107750477 @default.
• W2023267769 cites W2109810929 @default.
• W2023267769 cites W2113562511 @default.
• W2023267769 cites W2114072021 @default.
• W2023267769 cites W2122203682 @default.
• W2023267769 cites W2126941629 @default.
• W2023267769 cites W2128616172 @default.
• W2023267769 cites W2128882321 @default.
• W2023267769 cites W2132247441 @default.
• W2023267769 cites W2141350298 @default.
• W2023267769 cites W2142202085 @default.
• W2023267769 cites W2150322683 @default.
• W2023267769 cites W2156247249 @default.
• W2023267769 cites W2157774104 @default.
• W2023267769 cites W2161767156 @default.
• W2023267769 cites W2163250698 @default.
• W2023267769 cites W2170644493 @default.
• W2023267769 doi "https://doi.org/10.1016/j.micinf.2014.03.010" @default.
• W2023267769 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24726700" @default.
• W2023267769 hasPublicationYear "2014" @default.
• W2023267769 type Work @default.
• W2023267769 sameAs 2023267769 @default.
• W2023267769 citedByCount "9" @default.
• W2023267769 countsByYear W20232677692015 @default.
• W2023267769 countsByYear W20232677692016 @default.
• W2023267769 countsByYear W20232677692017 @default.
• W2023267769 countsByYear W20232677692018 @default.
• W2023267769 countsByYear W20232677692019 @default.
• W2023267769 countsByYear W20232677692020 @default.
• W2023267769 countsByYear W20232677692021 @default.
• W2023267769 crossrefType "journal-article" @default.
• W2023267769 hasAuthorship W2023267769A5058786642 @default.
• W2023267769 hasAuthorship W2023267769A5089723879 @default.
• W2023267769 hasAuthorship W2023267769A5091101919 @default.
• W2023267769 hasConcept C104317684 @default.
• W2023267769 hasConcept C130211564 @default.
• W2023267769 hasConcept C138626823 @default.
• W2023267769 hasConcept C156399914 @default.
• W2023267769 hasConcept C2776986154 @default.
• W2023267769 hasConcept C2781217973 @default.
• W2023267769 hasConcept C28406088 @default.
• W2023267769 hasConcept C49039625 @default.
• W2023267769 hasConcept C51785407 @default.
• W2023267769 hasConcept C54355233 @default.
• W2023267769 hasConcept C547475151 @default.
• W2023267769 hasConcept C55493867 @default.
• W2023267769 hasConcept C57581600 @default.
• W2023267769 hasConcept C60987743 @default.
• W2023267769 hasConcept C86803240 @default.
• W2023267769 hasConcept C89423630 @default.
• W2023267769 hasConcept C95444343 @default.
• W2023267769 hasConceptScore W2023267769C104317684 @default.
• W2023267769 hasConceptScore W2023267769C130211564 @default.
• W2023267769 hasConceptScore W2023267769C138626823 @default.
• W2023267769 hasConceptScore W2023267769C156399914 @default.
• W2023267769 hasConceptScore W2023267769C2776986154 @default.
• W2023267769 hasConceptScore W2023267769C2781217973 @default.
• W2023267769 hasConceptScore W2023267769C28406088 @default.
• W2023267769 hasConceptScore W2023267769C49039625 @default.
• W2023267769 hasConceptScore W2023267769C51785407 @default.

• next