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- W2023271312 abstract "Abstract Bacille Calmette-Guérin (BCG) is an attenuated strain of Mycobacterium bovis currently used as a vaccine against tuberculosis. Global distribution and propagation of BCG has contributed to the in vitro evolution of the vaccine strain and is thought to partially account for the different outcomes of BCG vaccine trials. Previous efforts by several molecular techniques effectively identified large sequence polymorphisms among BCG daughter strains, but lacked the resolution to identify smaller changes. In this study, we have used a NimbleGen tiling array for whole genome comparison of 13 BCG strains. Using this approach, in tandem with DNA resequencing, we have identified six novel large sequence polymorphisms including four deletions and two duplications in specific BCG strains. Moreover, we have uncovered various polymorphisms in the phoP-phoR locus. Importantly, these polymorphisms affect genes encoding established virulence factors including cell wall complex lipids, ESX secretion systems, and the PhoP-PhoR two-component system. Our study demonstrates that major virulence factors are different among BCG strains, which provide molecular mechanisms for important vaccine phenotypes including adverse effect profile, tuberculin reactivity and protective efficacy. These findings have important implications for the development of a new generation of vaccines." @default.
- W2023271312 created "2016-06-24" @default.
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- W2023271312 date "2008-09-15" @default.
- W2023271312 modified "2023-10-11" @default.
- W2023271312 title "Novel genome polymorphisms in BCG vaccine strains and impact on efficacy" @default.
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- W2023271312 cites W1977574443 @default.
- W2023271312 cites W1979528550 @default.
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- W2023271312 cites W1980485019 @default.
- W2023271312 cites W1985004048 @default.
- W2023271312 cites W2006252982 @default.
- W2023271312 cites W2006737804 @default.
- W2023271312 cites W2007203469 @default.
- W2023271312 cites W2010320265 @default.
- W2023271312 cites W2013972132 @default.
- W2023271312 cites W2015516142 @default.
- W2023271312 cites W2016805117 @default.
- W2023271312 cites W2018995059 @default.
- W2023271312 cites W2020490055 @default.
- W2023271312 cites W2021289012 @default.
- W2023271312 cites W2024974612 @default.
- W2023271312 cites W2024988038 @default.
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- W2023271312 cites W2036218860 @default.
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- W2023271312 cites W2052791500 @default.
- W2023271312 cites W2053951102 @default.
- W2023271312 cites W2058568534 @default.
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- W2023271312 cites W2066973840 @default.
- W2023271312 cites W2067834832 @default.
- W2023271312 cites W2075477269 @default.
- W2023271312 cites W2085097483 @default.
- W2023271312 cites W2085318854 @default.
- W2023271312 cites W2086083146 @default.
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- W2023271312 cites W2093423705 @default.
- W2023271312 cites W2095214972 @default.
- W2023271312 cites W2097340122 @default.
- W2023271312 cites W2101427564 @default.
- W2023271312 cites W2101666067 @default.
- W2023271312 cites W2103918519 @default.
- W2023271312 cites W2106456776 @default.
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- W2023271312 cites W2158199481 @default.
- W2023271312 cites W2168781976 @default.
- W2023271312 cites W2171080270 @default.
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- W2023271312 doi "https://doi.org/10.1186/1471-2164-9-413" @default.
- W2023271312 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2553098" @default.
- W2023271312 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18793412" @default.
- W2023271312 hasPublicationYear "2008" @default.
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