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• W2023272589 abstract "Atopic eczema (AE) is a chronic inflammatory skin disorder, characterized by impaired skin barrier and itch. The yeast Malassezia belongs to the normal human skin microflora and can induce IgE- and T-cell-mediated allergic reactions in AE patients. Previously, we have identified several IgE-binding components in Malassezia sympodialis extract.Here, we report cloning, production and characterization of a M. sympodialis 67-kDa allergen.The sequence of the 67-kDa protein, termed Mala s 12, showed sequence similarity to the glucose-methanol-choline (GMC) oxidoreductase enzyme superfamily and was expressed as a recombinant protein in Escherichia coli. The purified protein bound flavin adenine dinucleotide with 1:1 stoichiometry per monomer of protein. The protein-bound flavin showed an extinction coefficient at 451 nm of 11.3 mM(-1)cm(-1). The recombinant 67-kDa protein did not show any enzymatic activity when tested as oxidase or dehydrogenase using choline, glucose, myo-inositol, methanol, ethanol, 1-pentanol, benzyl alcohol, 2-phenylethanol, cholesterol or lauryl alcohol as possible substrates. Recombinant Mala s 12 was recognized by serum IgE from 13 of 21 (62%) M. sympodialis-sensitized AE patients indicating that the 67-kDa component is a major allergen.The data show that Mala s 12 has sequence similarity to the GMC oxidoreductase family and is a major allergen in AE patients." @default.
• W2023272589 created "2016-06-24" @default.
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• W2023272589 date "2007-02-20" @default.
• W2023272589 modified "2023-10-10" @default.
• W2023272589 title "Mala s 12 is a major allergen in patients with atopic eczema and has sequence similarities to the GMC oxidoreductase family" @default.
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• W2023272589 doi "https://doi.org/10.1111/j.1398-9995.2006.01291.x" @default.
• W2023272589 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17313403" @default.
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