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• W2023272972 abstract "The Tat protein of HIV-1 plays an essential role in HIV gene expression by promoting efficient elongation of viral transcripts. Posttranslational modifications of Tat fine-tune interactions of Tat with cellular cofactors and TAR RNA, a stem-loop structure at the 5' ends of viral transcripts. Here, we identify the lysine methyltransferase Set7/9 (KMT7) as a coactivator of HIV transcription. Set7/9-KMT7 associates with the HIV promoter in vivo and monomethylates lysine 51, a highly conserved residue located in the RNA-binding domain of Tat. Knockdown of Set7/9-KMT7 suppresses Tat transactivation of the HIV promoter, but does not affect the transcriptional activity of methylation-deficient Tat (K51A). Set7/9-KMT7 binds TAR RNA by itself and in complex with Tat and the positive transcription elongation factor P-TEFb. Our findings uncover a positive role for Set7/9-KMT7 and Tat methylation during early steps of the Tat transactivation cycle." @default.
• W2023272972 created "2016-06-24" @default.
• W2023272972 creator A5005385692 @default.
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• W2023272972 creator A5091496526 @default.
• W2023272972 date "2010-03-01" @default.
• W2023272972 modified "2023-10-14" @default.
• W2023272972 title "The Cellular Lysine Methyltransferase Set7/9-KMT7 Binds HIV-1 TAR RNA, Monomethylates the Viral Transactivator Tat, and Enhances HIV Transcription" @default.
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• W2023272972 doi "https://doi.org/10.1016/j.chom.2010.02.005" @default.
• W2023272972 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2844784" @default.
• W2023272972 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20227666" @default.
• W2023272972 hasPublicationYear "2010" @default.
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