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- W2023273015 abstract "Background: Cohen's hypothesis states that pulmonary dysfunction is the underlying unifying factor that leads to numerous health risks of inhaled toxicants. Objective: To test the idea postulated by Cohen. Methods: We compiled a retrospective cohort (n = 8024) composed of participants in eight population-based research and occupational studies conducted between 1977 and 1989. Smoking history, occupational exposures, health indicators, and demographic information were obtained by questionnaire. Pulmonary function was assessed by spirometry. Results: Cox proportional hazards models were utilized to test the Cohen's hypothesis. Risk of developing cancer increased (hazard ratio, 1.31; 95% confidence interval, 1.02 to 1.67) if a subject had an obstructive pulmonary disease at baseline. Conclusion: Impaired lung function caused by environmental and occupational exposures is one of the risk factors for the incidence of cancer." @default.
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- W2023273015 date "2012-12-01" @default.
- W2023273015 modified "2023-09-24" @default.
- W2023273015 title "Association Between Pulmonary Dysfunction as a Result of Occupational Exposures and Risk of Developing Cancer" @default.
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- W2023273015 doi "https://doi.org/10.1097/jom.0b013e3182623095" @default.
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