FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023273561> ?p ?o ?g. }

• W2023273561 endingPage "1640" @default.
• W2023273561 startingPage "1632" @default.
• W2023273561 abstract "The presence of a conserved protein motif usually implies common functional features. Here, we focused on the LisH (LIS1 homology) domain, which is found in multiple proteins, and have focused on three involved in human genetic diseases; LIS1, Transducin beta-like 1X (TBL1) and Oral-facial-digital type 1 (OFD1). The recently solved structure of the LisH domain in the N-terminal region of LIS1 depicted it as a novel dimerization motif. Our findings indicated that the LisH domain of both LIS1 and TBL1 is essential for in vitro oligomerization. Furthermore, our study disclosed novel in vivo features of the LisH motif. Mutationsin conserved LisH amino acids significantly reduced both the protein half-life of LIS1, TBL1, and OFD1, and dramatically affected specific intracellular localizations of these proteins. LIS1 mutated in the LisH domain induced its localization to the actin filaments. TBL1 mutated in the LisH domain was not imported into the nucleus. Mutations in OFD1 modified its localization to the Golgi apparatus and in some cases also to the nucleus. In summary, the LisH domain may participate in protein dimerization, affect protein half-life, and may influence specific cellular localizations. Our results allow the prediction that mutations withinthe LisH motif are likely to result in pathogenic consequences in genes associated with genetic diseases." @default.
• W2023273561 created "2016-06-24" @default.
• W2023273561 creator A5025814998 @default.
• W2023273561 creator A5028552359 @default.
• W2023273561 creator A5049504205 @default.
• W2023273561 creator A5057052702 @default.
• W2023273561 creator A5066004697 @default.
• W2023273561 date "2005-08-22" @default.
• W2023273561 modified "2023-10-16" @default.
• W2023273561 title "Novel Functional Features of the LIS-H Domain: Role in Protein Dimerization, Half-Life and Cellular Localization" @default.
• W2023273561 cites W1484403133 @default.
• W2023273561 cites W1484928190 @default.
• W2023273561 cites W1896987527 @default.
• W2023273561 cites W1964212058 @default.
• W2023273561 cites W1968444384 @default.
• W2023273561 cites W1969097053 @default.
• W2023273561 cites W1972111689 @default.
• W2023273561 cites W1973046803 @default.
• W2023273561 cites W1986281828 @default.
• W2023273561 cites W1992502425 @default.
• W2023273561 cites W2005748892 @default.
• W2023273561 cites W2007499634 @default.
• W2023273561 cites W2007629131 @default.
• W2023273561 cites W2007764809 @default.
• W2023273561 cites W2013671246 @default.
• W2023273561 cites W2028725230 @default.
• W2023273561 cites W2030311719 @default.
• W2023273561 cites W2036677133 @default.
• W2023273561 cites W2037312424 @default.
• W2023273561 cites W2044321794 @default.
• W2023273561 cites W2058549524 @default.
• W2023273561 cites W2067340269 @default.
• W2023273561 cites W2069532898 @default.
• W2023273561 cites W2072793384 @default.
• W2023273561 cites W2077673061 @default.
• W2023273561 cites W2096958727 @default.
• W2023273561 cites W2109627636 @default.
• W2023273561 cites W2115446838 @default.
• W2023273561 cites W2122770283 @default.
• W2023273561 cites W2125625974 @default.
• W2023273561 cites W2128647989 @default.
• W2023273561 cites W2133536539 @default.
• W2023273561 cites W2133666768 @default.
• W2023273561 cites W2133742333 @default.
• W2023273561 cites W2142137533 @default.
• W2023273561 cites W2143255074 @default.
• W2023273561 cites W2144065739 @default.
• W2023273561 cites W2151431457 @default.
• W2023273561 cites W2152052588 @default.
• W2023273561 cites W2156575042 @default.
• W2023273561 cites W2158266834 @default.
• W2023273561 cites W2165116262 @default.
• W2023273561 cites W2165343647 @default.
• W2023273561 cites W2172295707 @default.
• W2023273561 cites W2204309295 @default.
• W2023273561 doi "https://doi.org/10.4161/cc.4.11.2151" @default.
• W2023273561 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16258276" @default.
• W2023273561 hasPublicationYear "2005" @default.
• W2023273561 type Work @default.
• W2023273561 sameAs 2023273561 @default.
• W2023273561 citedByCount "79" @default.
• W2023273561 countsByYear W20232735612012 @default.
• W2023273561 countsByYear W20232735612013 @default.
• W2023273561 countsByYear W20232735612014 @default.
• W2023273561 countsByYear W20232735612015 @default.
• W2023273561 countsByYear W20232735612016 @default.
• W2023273561 countsByYear W20232735612017 @default.
• W2023273561 countsByYear W20232735612018 @default.
• W2023273561 countsByYear W20232735612019 @default.
• W2023273561 countsByYear W20232735612020 @default.
• W2023273561 countsByYear W20232735612021 @default.
• W2023273561 countsByYear W20232735612022 @default.
• W2023273561 countsByYear W20232735612023 @default.
• W2023273561 crossrefType "journal-article" @default.
• W2023273561 hasAuthorship W2023273561A5025814998 @default.
• W2023273561 hasAuthorship W2023273561A5028552359 @default.
• W2023273561 hasAuthorship W2023273561A5049504205 @default.
• W2023273561 hasAuthorship W2023273561A5057052702 @default.
• W2023273561 hasAuthorship W2023273561A5066004697 @default.
• W2023273561 hasBestOaLocation W20232735611 @default.
• W2023273561 hasConcept C104317684 @default.
• W2023273561 hasConcept C119062480 @default.
• W2023273561 hasConcept C144292202 @default.
• W2023273561 hasConcept C1491633281 @default.
• W2023273561 hasConcept C204491159 @default.
• W2023273561 hasConcept C29512474 @default.
• W2023273561 hasConcept C54355233 @default.
• W2023273561 hasConcept C70721500 @default.
• W2023273561 hasConcept C86339819 @default.
• W2023273561 hasConcept C86803240 @default.
• W2023273561 hasConcept C95444343 @default.
• W2023273561 hasConceptScore W2023273561C104317684 @default.
• W2023273561 hasConceptScore W2023273561C119062480 @default.
• W2023273561 hasConceptScore W2023273561C144292202 @default.
• W2023273561 hasConceptScore W2023273561C1491633281 @default.
• W2023273561 hasConceptScore W2023273561C204491159 @default.
• W2023273561 hasConceptScore W2023273561C29512474 @default.
• W2023273561 hasConceptScore W2023273561C54355233 @default.

• next