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- W2023274540 abstract "Activation of large conductance calcium-dependent potassium channels (BK channels) affects the membrane repolarization at action potential generation and the resting potential of detrusor smooth muscle cells (SMC). Overactive bladder syndrome (OBS) is one of the complications of diabetes mellitus. Using patch-clamp technique, we have found a significant decrease in potassium current (IBK) through BK channels of isolated detrusor SMC, and a decrease in the amplitude and frequency of BK-mediated spontaneous transient outward currents (STOCs) in rats with streptozotocin-induced diabetes mellitus compared with control animals. Under the diabetes, IBK density at step depolarization to +50 mV averaged (10.0 ± 0.5) pA / pF (the control values were (15.0 ± 0.4) pA / pF), whereas the mean values of the STOC frequency and amplitude at holding potential of -20 mV decreased from (12.0 ± 1.5) Hz to (2.4 ± 0.6) Hz and (0.9 ± 0.1) to 0.5 pA / pF ± 0.1 pA / pF, respectively. Using real time polymerase chain reaction (RT-PCR), it was found that mRNA expression of primary pore-forming KCa1.1-subunit of the BK channel increased in diabetes, whilst that for the auxiliary BKCaβ1-subunit decreased. It has been concluded that the observed changes in BK-channel currents in diabetes may enhance excitability of detrusor SMC, thereby promoting myogenic OBS. However, more studies are needed to determine how a decrease in BKCa β1 expression affects the functional properties of BK channels in diabetes, and to identify the type and direction of calcium signal changes modulating channel activation." @default.
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- W2023274540 date "2012-01-01" @default.
- W2023274540 modified "2023-09-27" @default.
- W2023274540 title "Changes in Calcium-Dependent Potassium Conductance of Isolated Smooth Muscle Cells of the Rat Bladder in Experimental Diabetes" @default.
- W2023274540 doi "https://doi.org/10.1615/intjphyspathophys.v3.i1.80" @default.
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