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- W2023275891 abstract "Although the advent of marketed transdermal drug-delivery products is nearing three decades, considerable strides in this noninvasive route of administration have been slow compared with its intravenous and oral counterparts, primarily due to the extreme barrier capabilities of the skin. The development of prodrug and codrug systems provides opportunity to enhance drug flux through the skin and thereby create highly desirable and efficacious treatment. The pharmacologically inactive prodrug is synthesized to increase or maximize its transdermal diffusion capabilities and then metabolized in vivo to the active compound. Similarly, codrugs are mutual prodrugs that are linked together in order to improve the drug-delivery properties of one or both drugs. This article reviews the current advances in prodrug and codrug transdermal therapy and their respective mechanisms for improvement in percutaneous absorption." @default.
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- W2023275891 date "2008-04-01" @default.
- W2023275891 modified "2023-09-23" @default.
- W2023275891 title "Prodrugs and codrugs as strategies for improving percutaneous absorption" @default.
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- W2023275891 doi "https://doi.org/10.1586/17469872.3.2.221" @default.
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