FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023276228> ?p ?o ?g. }

• W2023276228 endingPage "353" @default.
• W2023276228 startingPage "347" @default.
• W2023276228 abstract "To determine whether the expression of DNA damage detection and repair proteins is frequently altered in breast carcinomas.The expression profiles of five such proteins: ATM, p53, NBS1, MRE11 and Rad50 were analysed in 99 in-situ and invasive ductal breast carcinomas of different grades using an immunohistochemical approach, and compared with those seen in eight independent non-cancer (normal) breast samples and in the surrounding normal tissues of the breast carcinomas examined. ATM protein expression was reduced in 75% of the tumours compared with the levels found in normal tissues. Fewer tumours had reduced protein levels of the members of the MRE11, NBS1 and Rad50 (MNR) complex (31%, 46% and 28%, respectively) with p53 being over-expressed in 30%. In the majority of tumours (92%) we observed a good correlation between the expression of the three proteins of the MNR complex with low NBS1, MRE11 or Rad50 expression rarely found alone, suggesting that this event occurs subsequently to the deregulation in expression of other DNA repair proteins.The pattern of protein changes observed supports our hypothesis that alterations in DNA double-strand break repair capacity are involved in mammary carcinogenesis." @default.
• W2023276228 created "2016-06-24" @default.
• W2023276228 creator A5019481184 @default.
• W2023276228 creator A5056364025 @default.
• W2023276228 creator A5061777679 @default.
• W2023276228 creator A5079971350 @default.
• W2023276228 creator A5081886381 @default.
• W2023276228 date "2003-09-26" @default.
• W2023276228 modified "2023-10-18" @default.
• W2023276228 title "Altered expression of DNA double-strand break detection and repair proteins in breast carcinomas" @default.
• W2023276228 cites W1489499258 @default.
• W2023276228 cites W1640182255 @default.
• W2023276228 cites W1967264277 @default.
• W2023276228 cites W1972710550 @default.
• W2023276228 cites W1976240148 @default.
• W2023276228 cites W2006299554 @default.
• W2023276228 cites W2012844245 @default.
• W2023276228 cites W2027701827 @default.
• W2023276228 cites W2031010326 @default.
• W2023276228 cites W2039531876 @default.
• W2023276228 cites W2068239457 @default.
• W2023276228 cites W2074615071 @default.
• W2023276228 cites W2081317679 @default.
• W2023276228 cites W2088871099 @default.
• W2023276228 cites W2106018842 @default.
• W2023276228 cites W2120365943 @default.
• W2023276228 cites W2127566231 @default.
• W2023276228 cites W2160234594 @default.
• W2023276228 cites W2164518522 @default.
• W2023276228 doi "https://doi.org/10.1046/j.1365-2559.2003.01713.x" @default.
• W2023276228 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14511253" @default.
• W2023276228 hasPublicationYear "2003" @default.
• W2023276228 type Work @default.
• W2023276228 sameAs 2023276228 @default.
• W2023276228 citedByCount "56" @default.
• W2023276228 countsByYear W20232762282012 @default.
• W2023276228 countsByYear W20232762282013 @default.
• W2023276228 countsByYear W20232762282014 @default.
• W2023276228 countsByYear W20232762282015 @default.
• W2023276228 countsByYear W20232762282016 @default.
• W2023276228 countsByYear W20232762282019 @default.
• W2023276228 countsByYear W20232762282021 @default.
• W2023276228 countsByYear W20232762282022 @default.
• W2023276228 countsByYear W20232762282023 @default.
• W2023276228 crossrefType "journal-article" @default.
• W2023276228 hasAuthorship W2023276228A5019481184 @default.
• W2023276228 hasAuthorship W2023276228A5056364025 @default.
• W2023276228 hasAuthorship W2023276228A5061777679 @default.
• W2023276228 hasAuthorship W2023276228A5079971350 @default.
• W2023276228 hasAuthorship W2023276228A5081886381 @default.
• W2023276228 hasConcept C104317684 @default.
• W2023276228 hasConcept C121608353 @default.
• W2023276228 hasConcept C134935766 @default.
• W2023276228 hasConcept C142724271 @default.
• W2023276228 hasConcept C143425029 @default.
• W2023276228 hasConcept C153911025 @default.
• W2023276228 hasConcept C203014093 @default.
• W2023276228 hasConcept C204232928 @default.
• W2023276228 hasConcept C2775984157 @default.
• W2023276228 hasConcept C502942594 @default.
• W2023276228 hasConcept C530470458 @default.
• W2023276228 hasConcept C54355233 @default.
• W2023276228 hasConcept C552990157 @default.
• W2023276228 hasConcept C555283112 @default.
• W2023276228 hasConcept C71924100 @default.
• W2023276228 hasConcept C86339819 @default.
• W2023276228 hasConcept C86803240 @default.
• W2023276228 hasConcept C94966510 @default.
• W2023276228 hasConceptScore W2023276228C104317684 @default.
• W2023276228 hasConceptScore W2023276228C121608353 @default.
• W2023276228 hasConceptScore W2023276228C134935766 @default.
• W2023276228 hasConceptScore W2023276228C142724271 @default.
• W2023276228 hasConceptScore W2023276228C143425029 @default.
• W2023276228 hasConceptScore W2023276228C153911025 @default.
• W2023276228 hasConceptScore W2023276228C203014093 @default.
• W2023276228 hasConceptScore W2023276228C204232928 @default.
• W2023276228 hasConceptScore W2023276228C2775984157 @default.
• W2023276228 hasConceptScore W2023276228C502942594 @default.
• W2023276228 hasConceptScore W2023276228C530470458 @default.
• W2023276228 hasConceptScore W2023276228C54355233 @default.
• W2023276228 hasConceptScore W2023276228C552990157 @default.
• W2023276228 hasConceptScore W2023276228C555283112 @default.
• W2023276228 hasConceptScore W2023276228C71924100 @default.
• W2023276228 hasConceptScore W2023276228C86339819 @default.
• W2023276228 hasConceptScore W2023276228C86803240 @default.
• W2023276228 hasConceptScore W2023276228C94966510 @default.
• W2023276228 hasIssue "4" @default.
• W2023276228 hasLocation W20232762281 @default.
• W2023276228 hasLocation W20232762282 @default.
• W2023276228 hasOpenAccess W2023276228 @default.
• W2023276228 hasPrimaryLocation W20232762281 @default.
• W2023276228 hasRelatedWork W2062067118 @default.
• W2023276228 hasRelatedWork W2086303565 @default.
• W2023276228 hasRelatedWork W2112005097 @default.
• W2023276228 hasRelatedWork W2122753398 @default.
• W2023276228 hasRelatedWork W2124837740 @default.
• W2023276228 hasRelatedWork W2604970350 @default.
• W2023276228 hasRelatedWork W2952132334 @default.

• next