Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023276447> ?p ?o ?g. }
- W2023276447 endingPage "140" @default.
- W2023276447 startingPage "134" @default.
- W2023276447 abstract "Abstract Hydroxytyrosol and tyrosol are phenolic compounds found in virgin olive oil. A number of health-related properties have been previously demonstrated for both. The aim of this study was to investigate the potential anti-angiogenic effects of these compounds. Three different types of endothelial cells were used in several in vitro assays designed to test the specific effects of tested compounds on different key steps of the angiogenic process. Only hydroxytyrosol (but not tyrosol) had significant inhibitory effects on endothelial cell proliferation, migration and “tubule-like” structure formation on Matrigel. Furthermore, hydroxytyrosol changed endothelial cell cycle distribution, with a remarkable increase of subG1 subpopulation, indicative of apoptotic cells. Finally, hydroxytyrosol also behaved as a potent inhibitor of the invasive potential of endothelial cells, as revealed by decreased matrix metalloproteinase 2 in conditioned media. For the first time, this study shows that only hydroxytyrosol (but not tyrosol) is a new multi-targeted anti-angiogenic compound." @default.
- W2023276447 created "2016-06-24" @default.
- W2023276447 creator A5007867177 @default.
- W2023276447 creator A5033418778 @default.
- W2023276447 creator A5052820518 @default.
- W2023276447 creator A5074847949 @default.
- W2023276447 date "2012-09-01" @default.
- W2023276447 modified "2023-10-16" @default.
- W2023276447 title "Evaluation of the anti-angiogenic potential of hydroxytyrosol and tyrosol, two bio-active phenolic compounds of extra virgin olive oil, in endothelial cell cultures" @default.
- W2023276447 cites W1551620887 @default.
- W2023276447 cites W1980052604 @default.
- W2023276447 cites W1984584032 @default.
- W2023276447 cites W1991776410 @default.
- W2023276447 cites W2002449811 @default.
- W2023276447 cites W2005100448 @default.
- W2023276447 cites W2009789674 @default.
- W2023276447 cites W2013940496 @default.
- W2023276447 cites W2030231242 @default.
- W2023276447 cites W2036213597 @default.
- W2023276447 cites W2039316416 @default.
- W2023276447 cites W2055155868 @default.
- W2023276447 cites W2063271572 @default.
- W2023276447 cites W2065589217 @default.
- W2023276447 cites W2068530858 @default.
- W2023276447 cites W2069995157 @default.
- W2023276447 cites W2070601248 @default.
- W2023276447 cites W2072844658 @default.
- W2023276447 cites W2074196937 @default.
- W2023276447 cites W2074632040 @default.
- W2023276447 cites W2077598197 @default.
- W2023276447 cites W2085373268 @default.
- W2023276447 cites W2107413452 @default.
- W2023276447 cites W2118944124 @default.
- W2023276447 cites W2120250499 @default.
- W2023276447 cites W2120895512 @default.
- W2023276447 cites W2131316166 @default.
- W2023276447 cites W2132004720 @default.
- W2023276447 cites W2138075066 @default.
- W2023276447 cites W2139984133 @default.
- W2023276447 cites W2141471350 @default.
- W2023276447 cites W2146998282 @default.
- W2023276447 cites W2151662221 @default.
- W2023276447 cites W2167139020 @default.
- W2023276447 cites W2237478816 @default.
- W2023276447 cites W2335748841 @default.
- W2023276447 cites W2419269917 @default.
- W2023276447 cites W2793323124 @default.
- W2023276447 doi "https://doi.org/10.1016/j.foodchem.2012.02.079" @default.
- W2023276447 hasPublicationYear "2012" @default.
- W2023276447 type Work @default.
- W2023276447 sameAs 2023276447 @default.
- W2023276447 citedByCount "52" @default.
- W2023276447 countsByYear W20232764472013 @default.
- W2023276447 countsByYear W20232764472014 @default.
- W2023276447 countsByYear W20232764472015 @default.
- W2023276447 countsByYear W20232764472016 @default.
- W2023276447 countsByYear W20232764472017 @default.
- W2023276447 countsByYear W20232764472018 @default.
- W2023276447 countsByYear W20232764472019 @default.
- W2023276447 countsByYear W20232764472020 @default.
- W2023276447 countsByYear W20232764472021 @default.
- W2023276447 countsByYear W20232764472022 @default.
- W2023276447 countsByYear W20232764472023 @default.
- W2023276447 crossrefType "journal-article" @default.
- W2023276447 hasAuthorship W2023276447A5007867177 @default.
- W2023276447 hasAuthorship W2023276447A5033418778 @default.
- W2023276447 hasAuthorship W2023276447A5052820518 @default.
- W2023276447 hasAuthorship W2023276447A5074847949 @default.
- W2023276447 hasConcept C185592680 @default.
- W2023276447 hasConcept C2775881703 @default.
- W2023276447 hasConcept C2778004101 @default.
- W2023276447 hasConcept C2781397249 @default.
- W2023276447 hasConcept C2988377048 @default.
- W2023276447 hasConcept C31903555 @default.
- W2023276447 hasConcept C55493867 @default.
- W2023276447 hasConcept C70899900 @default.
- W2023276447 hasConceptScore W2023276447C185592680 @default.
- W2023276447 hasConceptScore W2023276447C2775881703 @default.
- W2023276447 hasConceptScore W2023276447C2778004101 @default.
- W2023276447 hasConceptScore W2023276447C2781397249 @default.
- W2023276447 hasConceptScore W2023276447C2988377048 @default.
- W2023276447 hasConceptScore W2023276447C31903555 @default.
- W2023276447 hasConceptScore W2023276447C55493867 @default.
- W2023276447 hasConceptScore W2023276447C70899900 @default.
- W2023276447 hasIssue "1" @default.
- W2023276447 hasLocation W20232764471 @default.
- W2023276447 hasOpenAccess W2023276447 @default.
- W2023276447 hasPrimaryLocation W20232764471 @default.
- W2023276447 hasRelatedWork W2016329778 @default.
- W2023276447 hasRelatedWork W2219849914 @default.
- W2023276447 hasRelatedWork W2749825900 @default.
- W2023276447 hasRelatedWork W2753846656 @default.
- W2023276447 hasRelatedWork W2772330259 @default.
- W2023276447 hasRelatedWork W2803928116 @default.
- W2023276447 hasRelatedWork W2913058987 @default.
- W2023276447 hasRelatedWork W3185769472 @default.
- W2023276447 hasRelatedWork W3210461713 @default.
- W2023276447 hasRelatedWork W84627913 @default.