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- W2023276597 abstract "The continued recycling of ribosomes during protein synthesis in rabbit reticulocyte lysates at 37° requires an initiation factor whose activity is rapidly lost in the absence of added heme. Partially purified factor ( i ) fully maintains the polysomes; ( ii ) inhibits the association of 40S and 60S ribosomal subunits into single ribosomes; ( iii ) promotes the quantitative entry of added 60S subunits into polysomes; ( iv ) allows the accumulation of ribosomal subunits, instead of single ribosomes, when initiation is blocked with aurin tricarboxylate; and ( v ) is absolutely required for the binding of globin messenger RNA to ribosomes. These properties suggest that this mammalian initiation factor functions analogously to bacterial IF-3. In addition, the translational control of globin synthesis by heme is exerted, directly or indirectly, through this factor." @default.
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- W2023276597 title "Translational Control of Hemoglobin Synthesis by an Initiation Factor Required for Recycling of Ribosomes and for their Binding to Messenger RNA" @default.
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- W2023276597 doi "https://doi.org/10.1073/pnas.69.11.3317" @default.
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