FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023277538> ?p ?o ?g. }

• W2023277538 endingPage "e0122987" @default.
• W2023277538 startingPage "e0122987" @default.
• W2023277538 abstract "Thyroid hormone receptor (TR) agonists have been proposed as therapeutic agents to treat non-alcoholic fatty liver disease (NAFLD) and insulin resistance. We investigated the ability of the TR agonists GC-1 and KB2115 to reduce hepatic steatosis in ob/ob mice. Both compounds markedly reduced hepatic triglyceride levels and ameliorated hepatic steatosis. However, the amelioration of fatty liver was not sufficient to improve insulin sensitivity in these mice and reductions in hepatic triglycerides did not correlate with improvements in insulin sensitivity or glycemic control. Instead, the effects of TR activation on glycemia varied widely and were found to depend upon the time of treatment as well as the compound and dosage used. Lower doses of GC-1 were found to further impair glycemic control, while a higher dose of the same compound resulted in substantially improved glucose tolerance and insulin sensitivity, despite all doses being equally effective at reducing hepatic triglyceride levels. Improvements in glycemic control and insulin sensitivity were observed only in treatments that also increased body temperature, suggesting that the induction of thermogenesis may play a role in mediating these beneficial effects. These data illustrate that the relationship between TR activation and insulin sensitivity is complex and suggests that although TR agonists may have value in treating NAFLD, their effect on insulin sensitivity must also be considered." @default.
• W2023277538 created "2016-06-24" @default.
• W2023277538 creator A5018566584 @default.
• W2023277538 creator A5023207846 @default.
• W2023277538 creator A5030666305 @default.
• W2023277538 creator A5031784533 @default.
• W2023277538 creator A5060289667 @default.
• W2023277538 date "2015-04-07" @default.
• W2023277538 modified "2023-10-09" @default.
• W2023277538 title "The Amelioration of Hepatic Steatosis by Thyroid Hormone Receptor Agonists Is Insufficient to Restore Insulin Sensitivity in Ob/Ob Mice" @default.
• W2023277538 cites W1575263278 @default.
• W2023277538 cites W1972184436 @default.
• W2023277538 cites W1983696329 @default.
• W2023277538 cites W1984669793 @default.
• W2023277538 cites W1991454487 @default.
• W2023277538 cites W1992711332 @default.
• W2023277538 cites W1997209292 @default.
• W2023277538 cites W1997704546 @default.
• W2023277538 cites W2001425475 @default.
• W2023277538 cites W2005153574 @default.
• W2023277538 cites W2007558589 @default.
• W2023277538 cites W2015246839 @default.
• W2023277538 cites W2016021698 @default.
• W2023277538 cites W2026572644 @default.
• W2023277538 cites W2029473474 @default.
• W2023277538 cites W2032194057 @default.
• W2023277538 cites W2042726806 @default.
• W2023277538 cites W2055518919 @default.
• W2023277538 cites W2056728315 @default.
• W2023277538 cites W2065612971 @default.
• W2023277538 cites W2067796323 @default.
• W2023277538 cites W2075858435 @default.
• W2023277538 cites W2077256608 @default.
• W2023277538 cites W2079734741 @default.
• W2023277538 cites W2080884925 @default.
• W2023277538 cites W2085244013 @default.
• W2023277538 cites W2086102771 @default.
• W2023277538 cites W2097478986 @default.
• W2023277538 cites W2098988372 @default.
• W2023277538 cites W2130586216 @default.
• W2023277538 cites W2136014653 @default.
• W2023277538 cites W2139337228 @default.
• W2023277538 cites W2140282855 @default.
• W2023277538 cites W2149593528 @default.
• W2023277538 cites W2159560542 @default.
• W2023277538 cites W2162023168 @default.
• W2023277538 cites W2164577763 @default.
• W2023277538 cites W2168526937 @default.
• W2023277538 cites W4230280576 @default.
• W2023277538 cites W4254374385 @default.
• W2023277538 doi "https://doi.org/10.1371/journal.pone.0122987" @default.
• W2023277538 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4388544" @default.
• W2023277538 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25849936" @default.
• W2023277538 hasPublicationYear "2015" @default.
• W2023277538 type Work @default.
• W2023277538 sameAs 2023277538 @default.
• W2023277538 citedByCount "28" @default.
• W2023277538 countsByYear W20232775382015 @default.
• W2023277538 countsByYear W20232775382016 @default.
• W2023277538 countsByYear W20232775382017 @default.
• W2023277538 countsByYear W20232775382018 @default.
• W2023277538 countsByYear W20232775382019 @default.
• W2023277538 countsByYear W20232775382020 @default.
• W2023277538 countsByYear W20232775382021 @default.
• W2023277538 countsByYear W20232775382022 @default.
• W2023277538 countsByYear W20232775382023 @default.
• W2023277538 crossrefType "journal-article" @default.
• W2023277538 hasAuthorship W2023277538A5018566584 @default.
• W2023277538 hasAuthorship W2023277538A5023207846 @default.
• W2023277538 hasAuthorship W2023277538A5030666305 @default.
• W2023277538 hasAuthorship W2023277538A5031784533 @default.
• W2023277538 hasAuthorship W2023277538A5060289667 @default.
• W2023277538 hasBestOaLocation W20232775381 @default.
• W2023277538 hasConcept C126322002 @default.
• W2023277538 hasConcept C134018914 @default.
• W2023277538 hasConcept C2776175330 @default.
• W2023277538 hasConcept C2777391703 @default.
• W2023277538 hasConcept C2778163477 @default.
• W2023277538 hasConcept C2778772119 @default.
• W2023277538 hasConcept C2778913445 @default.
• W2023277538 hasConcept C2779134260 @default.
• W2023277538 hasConcept C2779306644 @default.
• W2023277538 hasConcept C2780473172 @default.
• W2023277538 hasConcept C71315377 @default.
• W2023277538 hasConcept C71924100 @default.
• W2023277538 hasConceptScore W2023277538C126322002 @default.
• W2023277538 hasConceptScore W2023277538C134018914 @default.
• W2023277538 hasConceptScore W2023277538C2776175330 @default.
• W2023277538 hasConceptScore W2023277538C2777391703 @default.
• W2023277538 hasConceptScore W2023277538C2778163477 @default.
• W2023277538 hasConceptScore W2023277538C2778772119 @default.
• W2023277538 hasConceptScore W2023277538C2778913445 @default.
• W2023277538 hasConceptScore W2023277538C2779134260 @default.
• W2023277538 hasConceptScore W2023277538C2779306644 @default.
• W2023277538 hasConceptScore W2023277538C2780473172 @default.
• W2023277538 hasConceptScore W2023277538C71315377 @default.
• W2023277538 hasConceptScore W2023277538C71924100 @default.
• W2023277538 hasIssue "4" @default.

• next