FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023278837> ?p ?o ?g. }

• W2023278837 abstract "Various types of nanoparticles such as quantum dots, magnetic nanoparticles, and liposomes have been studied for numerous biomedical applications. Among these nanoparticles, gold nanoparticles have been extensively exploited for various applications including drug delivery, imaging agents, biosensors, and computed tomography (CT) contrast agents because they have many advantages such as low cytotoxicity, easy size control, high x-ray absorption, unique optical and electrical properties. Stability of gold nanoparticles under physiological conditions is key step for biomedical application. Another key is the immobilization or conjugation of bioactive molecules on gold nanoparticles for targeted drug delivery, molecular imaging, and in vitro diagnosis. To satisfy these key requirements, we developed a novel random copolymer composed of a “surface anchor part” (thiol group), “antibiofouling part” (PEG), and “bioreactivity part” (carboxyl group) for gold surface modification in particular. A random polymer to modify the gold surface for targeting ligand conjugation or SPR (surface plasmon resonance) chip was synthesized using radical polymerization. The chemical structure of poly(SVE-r-mPEGMA-r-MA) is shown in Figure 1(a). This polymer consists of three parts: a S-4vinylbenzyl ethanethionate (SVE) monomer as the surfaceanchor part, poly(ethylene glycol) methyl ether methacrylate (mPEGMA) as the protein-resistant part, and methacrylic acid (MA) monomer as a functional group to conjugate biomolecules. The initial feed ratio (SVE: mPEGMA:MA, 2:2:1) was chosen for synthesizing polymer that have high antibiofouling effect and strong surface binding capacity. After radical polymerization, unreacted monomers were removed by dialysis. The structure of the polymer was confirmed using NMR. Peaks for the methoxy of the mPEGMA and the methyl of the SVE monomer were observed at 3.4 ppm and 2.3 ppm, respectively (Figure S1). The molecular weight of the polymer was Mn = 16 000, as measured by gel permeation chromatography (GPC). Next, we examined the ability of the polymer to coat the gold surface. First, the acetylated thiol of the polymer was deprotected using hydroxylamine to yield a free thiol group. Because several thiol groups in the polymer provide multipoint attachments to the gold surface, the polymer spontaneously forms monolayers on a gold surface. Because of the multiple attachments, the stability of the polymeric monolayers can be significantly improved when exposed to a buffer with a non-physiological pH, or oxidative chemical and electrochemical environments. A polymeric self-assembled monolayer (SAM) of the polymer on the gold surface was prepared by immersing the substrates in an ethanol solution of 0.2 wt % polymer. The polymer monolayer thickness was measured using ellipsometry. The ellipsometric thickness increased after immersion times of up to 4 h. After 4 h, the thickness of the films remained unchanged, and the thickness of the monolayer was approximately" @default.
• W2023278837 created "2016-06-24" @default.
• W2023278837 creator A5037369509 @default.
• W2023278837 creator A5068975174 @default.
• W2023278837 date "2012-06-20" @default.
• W2023278837 modified "2023-09-27" @default.
• W2023278837 title "Synthesis of Novel Copolymer for Selective Biomolecule Immobilization on Gold Surface" @default.
• W2023278837 cites W1533889036 @default.
• W2023278837 cites W1963807187 @default.
• W2023278837 cites W1964499125 @default.
• W2023278837 cites W1965428790 @default.
• W2023278837 cites W1998231383 @default.
• W2023278837 cites W1998333438 @default.
• W2023278837 cites W2002025851 @default.
• W2023278837 cites W2005292281 @default.
• W2023278837 cites W2010801401 @default.
• W2023278837 cites W2020178198 @default.
• W2023278837 cites W2038820733 @default.
• W2023278837 cites W2039086627 @default.
• W2023278837 cites W2050955429 @default.
• W2023278837 cites W2060386158 @default.
• W2023278837 cites W2061214110 @default.
• W2023278837 cites W2070947696 @default.
• W2023278837 cites W2079158600 @default.
• W2023278837 cites W2083790799 @default.
• W2023278837 cites W2104009735 @default.
• W2023278837 cites W2115639329 @default.
• W2023278837 cites W2125681226 @default.
• W2023278837 cites W2140537016 @default.
• W2023278837 cites W2166806803 @default.
• W2023278837 doi "https://doi.org/10.5012/bkcs.2012.33.6.2099" @default.
• W2023278837 hasPublicationYear "2012" @default.
• W2023278837 type Work @default.
• W2023278837 sameAs 2023278837 @default.
• W2023278837 citedByCount "0" @default.
• W2023278837 crossrefType "journal-article" @default.
• W2023278837 hasAuthorship W2023278837A5037369509 @default.
• W2023278837 hasAuthorship W2023278837A5068975174 @default.
• W2023278837 hasBestOaLocation W20232788371 @default.
• W2023278837 hasConcept C104819515 @default.
• W2023278837 hasConcept C106847996 @default.
• W2023278837 hasConcept C115537861 @default.
• W2023278837 hasConcept C132050475 @default.
• W2023278837 hasConcept C147789679 @default.
• W2023278837 hasConcept C155672457 @default.
• W2023278837 hasConcept C15920480 @default.
• W2023278837 hasConcept C166940927 @default.
• W2023278837 hasConcept C171250308 @default.
• W2023278837 hasConcept C178790620 @default.
• W2023278837 hasConcept C185592680 @default.
• W2023278837 hasConcept C188027245 @default.
• W2023278837 hasConcept C192562407 @default.
• W2023278837 hasConcept C21951064 @default.
• W2023278837 hasConcept C2775968528 @default.
• W2023278837 hasConcept C2777516009 @default.
• W2023278837 hasConcept C2779820397 @default.
• W2023278837 hasConcept C44228677 @default.
• W2023278837 hasConcept C49853544 @default.
• W2023278837 hasConcept C521977710 @default.
• W2023278837 hasConceptScore W2023278837C104819515 @default.
• W2023278837 hasConceptScore W2023278837C106847996 @default.
• W2023278837 hasConceptScore W2023278837C115537861 @default.
• W2023278837 hasConceptScore W2023278837C132050475 @default.
• W2023278837 hasConceptScore W2023278837C147789679 @default.
• W2023278837 hasConceptScore W2023278837C155672457 @default.
• W2023278837 hasConceptScore W2023278837C15920480 @default.
• W2023278837 hasConceptScore W2023278837C166940927 @default.
• W2023278837 hasConceptScore W2023278837C171250308 @default.
• W2023278837 hasConceptScore W2023278837C178790620 @default.
• W2023278837 hasConceptScore W2023278837C185592680 @default.
• W2023278837 hasConceptScore W2023278837C188027245 @default.
• W2023278837 hasConceptScore W2023278837C192562407 @default.
• W2023278837 hasConceptScore W2023278837C21951064 @default.
• W2023278837 hasConceptScore W2023278837C2775968528 @default.
• W2023278837 hasConceptScore W2023278837C2777516009 @default.
• W2023278837 hasConceptScore W2023278837C2779820397 @default.
• W2023278837 hasConceptScore W2023278837C44228677 @default.
• W2023278837 hasConceptScore W2023278837C49853544 @default.
• W2023278837 hasConceptScore W2023278837C521977710 @default.
• W2023278837 hasLocation W20232788371 @default.
• W2023278837 hasOpenAccess W2023278837 @default.
• W2023278837 hasPrimaryLocation W20232788371 @default.
• W2023278837 hasRelatedWork W1994076870 @default.
• W2023278837 hasRelatedWork W2049247120 @default.
• W2023278837 hasRelatedWork W2085622058 @default.
• W2023278837 hasRelatedWork W2146893450 @default.
• W2023278837 hasRelatedWork W2156221992 @default.
• W2023278837 hasRelatedWork W2184046224 @default.
• W2023278837 hasRelatedWork W2266593095 @default.
• W2023278837 hasRelatedWork W2318844498 @default.
• W2023278837 hasRelatedWork W2558969089 @default.
• W2023278837 hasRelatedWork W2581975976 @default.
• W2023278837 hasRelatedWork W2733160954 @default.
• W2023278837 hasRelatedWork W2804363204 @default.
• W2023278837 hasRelatedWork W2910381274 @default.
• W2023278837 hasRelatedWork W2911224370 @default.
• W2023278837 hasRelatedWork W2945659746 @default.
• W2023278837 hasRelatedWork W2984424753 @default.
• W2023278837 hasRelatedWork W652043882 @default.
• W2023278837 hasRelatedWork W851443106 @default.

• next