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• W2023281360 abstract "Trypanosoma cruzi, the ethiologic agent ofChagas disease (Chagas 1909), is transmittedthrough triatomine vectors during the meal on theinvertebrate host. The parasite displays quite dis-tinct morphological and functional forms, alternat-ing between replicative stages (epimastigotes in thevector midgut and amastigotes in vertebrate cells)and infective, non-dividing forms (metacyclictrypomastigotes in the vector, which are depositedtogether with feces and urine, and bloodstreamtrypomastigotes in mammals) (for revision seeBrener 1973, Zeledon 1974, Garcia & Azambuja1991, 1996, Gonzalez et al. 1998a).Because of the importance of Chagas diseasein Latin America a great effort has been devotedto develop an experimental model that could imi-tate basic features on T. cruzi life cycle in the in-vertebrate vector. Thus, we developed in our labo-ratory the Rhodnius prolixus model to study sev-eral parameters related to the high degree of inter-action between T. cruzi and invertebrate vector.Basically, this model implies in feeding of larvaeand adults of R. prolixus, through a special mem-brane feeding apparatus, on blood containing dif-ferent strains/clones of T. cruzi and, at differentintervals, determination of the number of parasitein the gut, urine and feces of the vector (see Garcia& Azambuja 1991, 1996, Gonzalez et al. 1998a,1999). Herein, we will describe experiments, us-ing this useful parasite-vector model, to elucidatesome mechanisms involved in the interaction T.cruzi-triatomine insect and also link insect factorswith the success or the failure of strains/clones ofparasites to establish the infection in the digestivetract of the vector." @default.
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• W2023281360 date "1999-09-01" @default.
• W2023281360 modified "2023-09-26" @default.
• W2023281360 title "Biological factors involving Trypanosoma cruzi life cycle in the invertebrate vector, Rhodnius prolixus" @default.
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• W2023281360 doi "https://doi.org/10.1590/s0074-02761999000700033" @default.
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