FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023281588> ?p ?o ?g. }

• W2023281588 endingPage "1417" @default.
• W2023281588 startingPage "1404" @default.
• W2023281588 abstract "It is known that chemotherapy induces alopecia in humans, with important psychological and social implications in spite of its reversibility. Among chemotherapeutic drugs, anthracyclines are widely used, yet cause severe alopecia. One of the causes for the elevated sensibility of hair follicles to anthracyclines, and to drugs in general, is the high proliferation rate of follicular epithelium and the long duration of the growth phase (up to 7 years in humans). To clarify the mechanism of anthracycline toxicity, we used a rat model and focused our attention on the morphological alterations in hair follicles induced by doxorubicin. We observed the progression of hair follicle degeneration in the epithelial and mesenchymal compartments until alopecia arose, by both light and electron microscopy. As a first sign of damage, significant apoptosis was detected in the proximal perifollicular connective tissue sheath and sporadically in the matrix, near the interface between matrix and follicular papilla. We propose the apoptotic remodeling of the mesenchymal compartment as a process that is fundamental to the progression of events leading to alopecia. Regarding the epithelial compartment, it is important to note that oncosis was observed in a large number of follicular cells in the outer root sheath during the last stages of hair follicle regression. This indicates that oncosis is involved in a major way in the damage of epithelial cells." @default.
• W2023281588 created "2016-06-24" @default.
• W2023281588 creator A5002395274 @default.
• W2023281588 creator A5028006680 @default.
• W2023281588 creator A5058707877 @default.
• W2023281588 creator A5067641046 @default.
• W2023281588 creator A5079183289 @default.
• W2023281588 date "2004-11-01" @default.
• W2023281588 modified "2023-10-05" @default.
• W2023281588 title "Epithelium–mesenchyme compartment interaction and oncosis on chemotherapy-induced hair damage" @default.
• W2023281588 cites W1964851035 @default.
• W2023281588 cites W1978190096 @default.
• W2023281588 cites W1999489764 @default.
• W2023281588 cites W2003029178 @default.
• W2023281588 cites W2007035176 @default.
• W2023281588 cites W2017959339 @default.
• W2023281588 cites W2024240665 @default.
• W2023281588 cites W2024883180 @default.
• W2023281588 cites W2027339280 @default.
• W2023281588 cites W2029135677 @default.
• W2023281588 cites W2029655229 @default.
• W2023281588 cites W2034690064 @default.
• W2023281588 cites W2045491202 @default.
• W2023281588 cites W2046960516 @default.
• W2023281588 cites W2051692033 @default.
• W2023281588 cites W2054618461 @default.
• W2023281588 cites W2059542071 @default.
• W2023281588 cites W2063745159 @default.
• W2023281588 cites W2068630823 @default.
• W2023281588 cites W2079497823 @default.
• W2023281588 cites W2081839886 @default.
• W2023281588 cites W2089194398 @default.
• W2023281588 cites W2091204831 @default.
• W2023281588 cites W2095424411 @default.
• W2023281588 cites W2106410559 @default.
• W2023281588 cites W2108447397 @default.
• W2023281588 cites W2121876008 @default.
• W2023281588 cites W2151910306 @default.
• W2023281588 cites W2153481530 @default.
• W2023281588 cites W2161644747 @default.
• W2023281588 cites W2162498821 @default.
• W2023281588 cites W2205931255 @default.
• W2023281588 cites W2313427064 @default.
• W2023281588 cites W2326545837 @default.
• W2023281588 cites W2406498477 @default.
• W2023281588 cites W4322697652 @default.
• W2023281588 doi "https://doi.org/10.1038/labinvest.3700170" @default.
• W2023281588 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15378070" @default.
• W2023281588 hasPublicationYear "2004" @default.
• W2023281588 type Work @default.
• W2023281588 sameAs 2023281588 @default.
• W2023281588 citedByCount "9" @default.
• W2023281588 countsByYear W20232815882012 @default.
• W2023281588 countsByYear W20232815882013 @default.
• W2023281588 countsByYear W20232815882018 @default.
• W2023281588 countsByYear W20232815882019 @default.
• W2023281588 crossrefType "journal-article" @default.
• W2023281588 hasAuthorship W2023281588A5002395274 @default.
• W2023281588 hasAuthorship W2023281588A5028006680 @default.
• W2023281588 hasAuthorship W2023281588A5058707877 @default.
• W2023281588 hasAuthorship W2023281588A5067641046 @default.
• W2023281588 hasAuthorship W2023281588A5079183289 @default.
• W2023281588 hasBestOaLocation W20232815881 @default.
• W2023281588 hasConcept C134018914 @default.
• W2023281588 hasConcept C142724271 @default.
• W2023281588 hasConcept C187785154 @default.
• W2023281588 hasConcept C2777216303 @default.
• W2023281588 hasConcept C2991961867 @default.
• W2023281588 hasConcept C529295009 @default.
• W2023281588 hasConcept C71924100 @default.
• W2023281588 hasConcept C86803240 @default.
• W2023281588 hasConcept C95444343 @default.
• W2023281588 hasConceptScore W2023281588C134018914 @default.
• W2023281588 hasConceptScore W2023281588C142724271 @default.
• W2023281588 hasConceptScore W2023281588C187785154 @default.
• W2023281588 hasConceptScore W2023281588C2777216303 @default.
• W2023281588 hasConceptScore W2023281588C2991961867 @default.
• W2023281588 hasConceptScore W2023281588C529295009 @default.
• W2023281588 hasConceptScore W2023281588C71924100 @default.
• W2023281588 hasConceptScore W2023281588C86803240 @default.
• W2023281588 hasConceptScore W2023281588C95444343 @default.
• W2023281588 hasIssue "11" @default.
• W2023281588 hasLocation W20232815881 @default.
• W2023281588 hasLocation W20232815882 @default.
• W2023281588 hasOpenAccess W2023281588 @default.
• W2023281588 hasPrimaryLocation W20232815881 @default.
• W2023281588 hasRelatedWork W1991869463 @default.
• W2023281588 hasRelatedWork W2030942943 @default.
• W2023281588 hasRelatedWork W2032129913 @default.
• W2023281588 hasRelatedWork W2041819610 @default.
• W2023281588 hasRelatedWork W2064379842 @default.
• W2023281588 hasRelatedWork W2095007914 @default.
• W2023281588 hasRelatedWork W2097664726 @default.
• W2023281588 hasRelatedWork W2412629816 @default.
• W2023281588 hasRelatedWork W2939434980 @default.
• W2023281588 hasRelatedWork W3172997974 @default.
• W2023281588 hasVolume "84" @default.
• W2023281588 isParatext "false" @default.

• next