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- W2023281637 abstract "The onset of the switchover from fetal to adult erythropoiesis is generally agreed to occur at about 32-36 weeks' post conceptual age. The time course of switching is subject to individual variation, as implied by the scatter in published data. However, the essentially cross-sectional nature of these studies fails to predict patterns of Hb switching in individuals. Such variations and their association with clinical correlates may therefore be missed. We present findings from 15 untransfused babies of 27-34 weeks gestation, studied prospectively till c. 52 weeks' post conceptual age; we monitored total haemoglobin (Hb) concentration and % HbF and derived from these a mathematical analysis allowing deduction of the timing of onset and subsequent rate of Hb switching. We found onset at 32-34 weeks' post conceptual age, with a mean half-time (t½) of 5 weeks. There was wide individual variation in the rate, with t½ of 1-8 weeks. Evaluation of the % HbF in concentrated reticulocytes (prepared using the Flourescence-Activated Cell Sorter) has allowed direct assessment of the validity of the predictions. Quantitation of individual variation in onset and rate of Hb switching allows correlation with specific clinical features. These might include placentofetal transfusion, drugs, stress erythropoiesis and red cell transfusions." @default.
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- W2023281637 date "1986-10-01" @default.
- W2023281637 modified "2023-09-26" @default.
- W2023281637 title "135 THE VARIABLE COURSE OF HbF to HbA SWITCHING IN PRETERM INFANTS: A BASIS DERIVED FROM MATHEMATICAL ANALYSIS FOR ASSESSMENT OF POSSIBLE CLINICAL INFLUENCES" @default.
- W2023281637 doi "https://doi.org/10.1203/00006450-198610000-00190" @default.
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