FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023282369> ?p ?o ?g. }

• W2023282369 endingPage "1204" @default.
• W2023282369 startingPage "1198" @default.
• W2023282369 abstract "1 We determined the effect of cyclosporine A (CsA) treatment on mast cell degranulation and lung resistance (RL) in vivo, and tracheal smooth muscle (TSM) contraction ex vivo after antigen challenge in sensitized cats. We also determined the direct effects of addition of CsA to the tissue bath on antigen-induced responses of TSM in vitro. 2 Cats (n=10) were sensitized by i.m. injection of Ascaris suum antigen (AA); 5 cats (CsA+) received CsA twice daily for 2 weeks before acute antigen challenge in doses sufficient to suppress interleukin-2 secretion from feline peripheral blood mononuclear cells ex vivo. 3 Lung resistance increased comparably within 10 min of exposure to AA (P<0.03). Histamine content in bronchoalveolar lavage fluid from both groups increased comparably within 30 min of antigen challenge, from undetectable levels to 542±74 pg ml−1 post AA for CsA+ and from 74±19 pg ml−1 at baseline, to 970±180 pg ml−1 post AA CsA− (P<0.05; P=NS vs CsA+). 4 In excised TSM, active tension elicited by exposure to AA in vitro was 107±38% KCl in the CsA+ group vs 144±56% KCl in the CsA− group (P=NS). However, contraction of TSM (n=4) harvested from both groups was abolished or greatly diminished after AA challenge when tissues were pre-incubated with 1 μM CsA in vitro (8±8% KCl, P<0.05 vs CsA+ and CsA−). This was associated with inhibited release of 5-hydroxytryptamine into the organ bath fluid of tissues treated with CsA in vitro only. 5 We demonstrated that CsA treatment in vivo does not inhibit the early phase asthmatic response or mast cell degranulation following antigen challenge in sensitized cats. Additionally, the effects of CsA on mast cell function ex vivo do not reflect lack of effects of CsA on mast cell function in vivo in this animal model of atopic asthma. British Journal of Pharmacology (1998) 123, 1198–1204; doi:10.1038/sj.bjp.0701716" @default.
• W2023282369 created "2016-06-24" @default.
• W2023282369 creator A5014966245 @default.
• W2023282369 creator A5048551626 @default.
• W2023282369 creator A5059073185 @default.
• W2023282369 creator A5065838563 @default.
• W2023282369 creator A5081083077 @default.
• W2023282369 creator A5088949751 @default.
• W2023282369 date "1998-03-01" @default.
• W2023282369 modified "2023-10-10" @default.
• W2023282369 title "Differential effects of cyclosporine A after acute antigen challenge in sensitized cats <i>in vivo</i> and <i>ex vivo</i>" @default.
• W2023282369 cites W1946327891 @default.
• W2023282369 cites W1983446181 @default.
• W2023282369 cites W1987272497 @default.
• W2023282369 cites W1988939115 @default.
• W2023282369 cites W1996394259 @default.
• W2023282369 cites W2028787412 @default.
• W2023282369 cites W2030681831 @default.
• W2023282369 cites W2040031020 @default.
• W2023282369 cites W2051387923 @default.
• W2023282369 cites W2054726375 @default.
• W2023282369 cites W2061092989 @default.
• W2023282369 cites W2065750004 @default.
• W2023282369 cites W2092957238 @default.
• W2023282369 cites W2107981202 @default.
• W2023282369 cites W2110956877 @default.
• W2023282369 cites W2120351346 @default.
• W2023282369 cites W2122666166 @default.
• W2023282369 cites W2141648152 @default.
• W2023282369 cites W2151900684 @default.
• W2023282369 cites W2158108461 @default.
• W2023282369 cites W2165312997 @default.
• W2023282369 cites W2339022261 @default.
• W2023282369 cites W2413351085 @default.
• W2023282369 cites W4249074344 @default.
• W2023282369 doi "https://doi.org/10.1038/sj.bjp.0701716" @default.
• W2023282369 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1565269" @default.
• W2023282369 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9559905" @default.
• W2023282369 hasPublicationYear "1998" @default.
• W2023282369 type Work @default.
• W2023282369 sameAs 2023282369 @default.
• W2023282369 citedByCount "23" @default.
• W2023282369 countsByYear W20232823692012 @default.
• W2023282369 countsByYear W20232823692013 @default.
• W2023282369 countsByYear W20232823692014 @default.
• W2023282369 countsByYear W20232823692015 @default.
• W2023282369 countsByYear W20232823692018 @default.
• W2023282369 countsByYear W20232823692019 @default.
• W2023282369 countsByYear W20232823692020 @default.
• W2023282369 countsByYear W20232823692021 @default.
• W2023282369 countsByYear W20232823692023 @default.
• W2023282369 crossrefType "journal-article" @default.
• W2023282369 hasAuthorship W2023282369A5014966245 @default.
• W2023282369 hasAuthorship W2023282369A5048551626 @default.
• W2023282369 hasAuthorship W2023282369A5059073185 @default.
• W2023282369 hasAuthorship W2023282369A5065838563 @default.
• W2023282369 hasAuthorship W2023282369A5081083077 @default.
• W2023282369 hasAuthorship W2023282369A5088949751 @default.
• W2023282369 hasBestOaLocation W20232823691 @default.
• W2023282369 hasConcept C1122143 @default.
• W2023282369 hasConcept C126322002 @default.
• W2023282369 hasConcept C147483822 @default.
• W2023282369 hasConcept C150903083 @default.
• W2023282369 hasConcept C170493617 @default.
• W2023282369 hasConcept C185592680 @default.
• W2023282369 hasConcept C202751555 @default.
• W2023282369 hasConcept C203014093 @default.
• W2023282369 hasConcept C207001950 @default.
• W2023282369 hasConcept C26291073 @default.
• W2023282369 hasConcept C2777714996 @default.
• W2023282369 hasConcept C2777961210 @default.
• W2023282369 hasConcept C2779904517 @default.
• W2023282369 hasConcept C49802076 @default.
• W2023282369 hasConcept C55493867 @default.
• W2023282369 hasConcept C71924100 @default.
• W2023282369 hasConcept C86803240 @default.
• W2023282369 hasConcept C98274493 @default.
• W2023282369 hasConceptScore W2023282369C1122143 @default.
• W2023282369 hasConceptScore W2023282369C126322002 @default.
• W2023282369 hasConceptScore W2023282369C147483822 @default.
• W2023282369 hasConceptScore W2023282369C150903083 @default.
• W2023282369 hasConceptScore W2023282369C170493617 @default.
• W2023282369 hasConceptScore W2023282369C185592680 @default.
• W2023282369 hasConceptScore W2023282369C202751555 @default.
• W2023282369 hasConceptScore W2023282369C203014093 @default.
• W2023282369 hasConceptScore W2023282369C207001950 @default.
• W2023282369 hasConceptScore W2023282369C26291073 @default.
• W2023282369 hasConceptScore W2023282369C2777714996 @default.
• W2023282369 hasConceptScore W2023282369C2777961210 @default.
• W2023282369 hasConceptScore W2023282369C2779904517 @default.
• W2023282369 hasConceptScore W2023282369C49802076 @default.
• W2023282369 hasConceptScore W2023282369C55493867 @default.
• W2023282369 hasConceptScore W2023282369C71924100 @default.
• W2023282369 hasConceptScore W2023282369C86803240 @default.
• W2023282369 hasConceptScore W2023282369C98274493 @default.
• W2023282369 hasIssue "6" @default.
• W2023282369 hasLocation W20232823691 @default.
• W2023282369 hasLocation W20232823692 @default.

• next