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- W2023282529 abstract "Replication licensing factor (RLF) is a multiprotein complex involved in ensuring that chromosomal DNA replicates only once in a single cell cycle. It comprises two components, termed RLF-M and RLF-B. Purified RLF-M consists of a mixture of complexes containing all six members of the MCM/P1 family of minichromosome maintenance proteins. The precise composition of these different complexes and their contribution to RLF-M activity has been unclear. Here we show that in Xenopus extracts, MCM/P1 proteins mainly form heterohexamers containing each of the six proteins. This heterohexamer is readily split into subcomplexes, whose interactions and subunit composition we characterize in detail. We show for the first time an ordered multistep assembly pathway by which the heterohexamer can be reformed from the subcomplexes. Importantly, this novel pathway is essential for DNA replication, since only the full heterohexamer can bind productively to chromatin and provide RLF-M activity." @default.
- W2023282529 created "2016-06-24" @default.
- W2023282529 creator A5017566265 @default.
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- W2023282529 date "2000-01-01" @default.
- W2023282529 modified "2023-09-29" @default.
- W2023282529 title "Sequential MCM/P1 Subcomplex Assembly Is Required to Form a Heterohexamer with Replication Licensing Activity" @default.
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- W2023282529 doi "https://doi.org/10.1074/jbc.275.4.2491" @default.
- W2023282529 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3626232" @default.
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