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- W2023282984 abstract "1. 1. Tissue oxygen uptake and enzyme activities were investigated in the naked mole rat, Heterocephalus glaber , a mammal notable for its low body temperature and metabolism and poor temperature regulating ability. 2. 2. Q 10 for O 2 uptake of Heterocephalus crude liver homogenates ranged from 1.91 for the temperature interval 25–30°C to 1.76 within the range 30–38°C, values similar to those reported for typical homoiotherms. 3. 3. K m pyruvate of lactate dehydrogenase in heart muscle had the same temperature dependence in the mole rat and mouse. 4. 4. O 2 uptake and cytochrome oxidase activity of skeletal muscle were higher for mole rat than mouse. The reverse was true for heart muscle. Brain and liver O 2 uptake showed similar values for both species, while kidney O 2 uptake was highest in the mouse. 5. 5. Pyruvate kinase activity in heart and skeletal muscle was higher in mouse than mole rat, suggesting a greater reliance on glycolysis in the former. 6. 6. Na + , K + -ATPase activity of liver and kidney was 60% higher in mouse than mole rat, while brain was 30% higher in mouse. 7. 7. The results indicate that the effects of temperature on tissue metabolism in the mole rat conform to those in typical homoiotherms. The low body temperature and O 2 uptake in the mole rat find no expression in the tissue respiratory capacity." @default.
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- W2023282984 date "1977-01-01" @default.
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- W2023282984 title "Tissue metabolism and enzyme activities in the rodent Heterocephalus glaber, a poor temperature regulator" @default.
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- W2023282984 doi "https://doi.org/10.1016/0305-0491(77)90056-6" @default.
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