Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023283005> ?p ?o ?g. }
Showing items 1 to 92 of
92
with 100 items per page.
- W2023283005 endingPage "309" @default.
- W2023283005 startingPage "303" @default.
- W2023283005 abstract "Total parenteral nutrition provides nutrition support in patients who are unable to eat. Long-term parenteral nutrition is accompanied by alterations in gut and liver function including changes in drug metabolism. This study examined the effects of lipid-free total parenteral nutrition in rats on (1) the overall elimination pharmacokinetics of acetaminophen, (2) changes in sulfation and glucuronidation pathways during acetaminophen elimination, and (3) hepatic drug metabolizing enzyme activities determined in vitro.Chronic indwelling catheters were implanted in the aorta, inferior vena cava, and portal vein of adult male Sprague-Dawley rats. Total parenteral nutrition, consisting of 25% dextrose, 5% amino acids, electrolytes, and vitamins, was infused via the portal vein for up to 14 days. Acetaminophen pharmacokinetics were characterized in vivo and selected drug metabolizing enzyme activities were determined in vitro.Parenteral nutrition for 10 days decreased the total clearance of acetaminophen by 23% (from 11.5 +/- 1.4 to 8.9 +/- 1.4 mL/min per kg; p < .05) and decreased the formation clearance to acetaminophen sulfate (from 6.2 +/- 0.4 to 3.9 +/- 0.5 mL/min per kg; p < .05). Parenteral nutrition decreased microsomal cytochrome P450 concentration (47%), p-nitroanisole demethylase activity (68%) and p-nitrophenol UDP-glucuronosyltransferase activity (58%). Cytosolic glutathione-S-transferase activity towards 1-chloro-2,4-dinitrobenzene decreased 29%. Sulfotransferase activity towards p-nitrophenol and acetaminophen was decreased 48% and 25%, respectively.Lipid-free, total parenteral nutrition depresses drug conjugative metabolism in rats. The magnitude of this effect in humans remains to be investigated." @default.
- W2023283005 created "2016-06-24" @default.
- W2023283005 creator A5036710124 @default.
- W2023283005 creator A5054148025 @default.
- W2023283005 creator A5075343231 @default.
- W2023283005 date "1995-07-01" @default.
- W2023283005 modified "2023-10-18" @default.
- W2023283005 title "The Depression of Hepatic Drug Conjugation Reactions in Rats After Lipid-Free Total Parenteral Nutrition Administered via the Portal Vein" @default.
- W2023283005 cites W1566417308 @default.
- W2023283005 cites W1607661535 @default.
- W2023283005 cites W1726400177 @default.
- W2023283005 cites W1991065335 @default.
- W2023283005 cites W2006338939 @default.
- W2023283005 cites W2015786246 @default.
- W2023283005 cites W2023899875 @default.
- W2023283005 cites W2045358800 @default.
- W2023283005 cites W2058435277 @default.
- W2023283005 cites W2073574286 @default.
- W2023283005 cites W2073812733 @default.
- W2023283005 cites W2078364946 @default.
- W2023283005 cites W2085112080 @default.
- W2023283005 cites W2088735480 @default.
- W2023283005 cites W2129120188 @default.
- W2023283005 cites W2131696859 @default.
- W2023283005 cites W2146985915 @default.
- W2023283005 cites W2255148483 @default.
- W2023283005 cites W268970733 @default.
- W2023283005 cites W86248671 @default.
- W2023283005 doi "https://doi.org/10.1177/0148607195019004303" @default.
- W2023283005 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8523630" @default.
- W2023283005 hasPublicationYear "1995" @default.
- W2023283005 type Work @default.
- W2023283005 sameAs 2023283005 @default.
- W2023283005 citedByCount "3" @default.
- W2023283005 crossrefType "journal-article" @default.
- W2023283005 hasAuthorship W2023283005A5036710124 @default.
- W2023283005 hasAuthorship W2023283005A5054148025 @default.
- W2023283005 hasAuthorship W2023283005A5075343231 @default.
- W2023283005 hasConcept C112705442 @default.
- W2023283005 hasConcept C126322002 @default.
- W2023283005 hasConcept C134018914 @default.
- W2023283005 hasConcept C181199279 @default.
- W2023283005 hasConcept C185592680 @default.
- W2023283005 hasConcept C2777513400 @default.
- W2023283005 hasConcept C2778722691 @default.
- W2023283005 hasConcept C2779907587 @default.
- W2023283005 hasConcept C2780035454 @default.
- W2023283005 hasConcept C44315111 @default.
- W2023283005 hasConcept C55493867 @default.
- W2023283005 hasConcept C71924100 @default.
- W2023283005 hasConcept C78722104 @default.
- W2023283005 hasConcept C87644729 @default.
- W2023283005 hasConcept C89311334 @default.
- W2023283005 hasConcept C98274493 @default.
- W2023283005 hasConceptScore W2023283005C112705442 @default.
- W2023283005 hasConceptScore W2023283005C126322002 @default.
- W2023283005 hasConceptScore W2023283005C134018914 @default.
- W2023283005 hasConceptScore W2023283005C181199279 @default.
- W2023283005 hasConceptScore W2023283005C185592680 @default.
- W2023283005 hasConceptScore W2023283005C2777513400 @default.
- W2023283005 hasConceptScore W2023283005C2778722691 @default.
- W2023283005 hasConceptScore W2023283005C2779907587 @default.
- W2023283005 hasConceptScore W2023283005C2780035454 @default.
- W2023283005 hasConceptScore W2023283005C44315111 @default.
- W2023283005 hasConceptScore W2023283005C55493867 @default.
- W2023283005 hasConceptScore W2023283005C71924100 @default.
- W2023283005 hasConceptScore W2023283005C78722104 @default.
- W2023283005 hasConceptScore W2023283005C87644729 @default.
- W2023283005 hasConceptScore W2023283005C89311334 @default.
- W2023283005 hasConceptScore W2023283005C98274493 @default.
- W2023283005 hasIssue "4" @default.
- W2023283005 hasLocation W20232830051 @default.
- W2023283005 hasLocation W20232830052 @default.
- W2023283005 hasOpenAccess W2023283005 @default.
- W2023283005 hasPrimaryLocation W20232830051 @default.
- W2023283005 hasRelatedWork W1969876219 @default.
- W2023283005 hasRelatedWork W2015484631 @default.
- W2023283005 hasRelatedWork W2047425497 @default.
- W2023283005 hasRelatedWork W2217131896 @default.
- W2023283005 hasRelatedWork W2253774159 @default.
- W2023283005 hasRelatedWork W2748952813 @default.
- W2023283005 hasRelatedWork W28666504 @default.
- W2023283005 hasRelatedWork W4205993769 @default.
- W2023283005 hasRelatedWork W4324335433 @default.
- W2023283005 hasRelatedWork W4366188202 @default.
- W2023283005 hasVolume "19" @default.
- W2023283005 isParatext "false" @default.
- W2023283005 isRetracted "false" @default.
- W2023283005 magId "2023283005" @default.
- W2023283005 workType "article" @default.