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- W2023283144 abstract "Objective To develop a model for prediction of spontaneous delivery before 34 weeks based on maternal factors, placental perfusion and function at 11–13 weeks' gestation. Methods Two groups of studies: first, screening study of maternal characteristics, serum pregnancy-associated plasma protein-A (PAPP-A), free β-human chorionic gonadotrophin (β-hCG) and uterine artery pulsatility index (PI). Second, case-control studies of maternal serum or plasma concentration of placental growth factor (PlGF), placental protein 13 (PP13), a disintegrin and metalloprotease 12 (ADAM12), inhibin-A and activin-A. Regression analysis was used to develop a model for the prediction of spontaneous early delivery. Results Spontaneous early delivery occurred in 365 (1.1%) of the 34 025 pregnancies. A model based on maternal factors could detect 38.2% of the preterm deliveries in women with previous pregnancies at or beyond 16 weeks and 18.4% in those without, at a false positive rate (FPR) of 10%. In the preterm delivery group, compared with unaffected pregnancies there were no significant differences in the markers of placental perfusion or function, except for PAPP-A which was reduced. Conclusions Patient-specific risk of preterm delivery is provided by maternal factors and obstetric history. Placental perfusion and function at 11–13 weeks are not altered in pregnancies resulting in spontaneous early delivery. Copyright © 2011 John Wiley & Sons, Ltd." @default.
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- W2023283144 date "2011-01-01" @default.
- W2023283144 modified "2023-10-03" @default.
- W2023283144 title "Prediction of spontaneous preterm delivery from maternal factors, obstetric history and placental perfusion and function at 11-13 weeks" @default.
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- W2023283144 doi "https://doi.org/10.1002/pd.2662" @default.
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