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• W2023283306 abstract "Cholesterol side-chain cleavage activity (cholesterol SCC) in a mitochondrial preparation is increased by calcium in a sigmoidal manner. A 5-10-fold increase is obtained and an effect may be seen at 20 microM CaCl2. ADP inhibits the stimulation by calcium with a shift of the sigmoid curve to the right and 10 microM ADP results in a 4-fold increase in the amount of CaCl2 required to obtain one-half the maximal stimulation value. The inhibition is specific for ADP and inhibition by ATP is due to the formation of ADP. The characteristics of the calcium-ADP modulation are such that a suitable ADP-inhibited level of cholesterol sidechain cleavage activity will be stimulated by a given increment of calcium to a greater extent than in the absence of the added ADP. Steroid 11 beta-hydroxylation is also stimulated in a sigmoidal manner by calcium and this stimulation is inhibited by ADP. The 11 beta-hydroxylation, however, is less sensitive to calcium and ADP so that changes in cholesterol SCC are obtained at concentration of calcium and ADP where minimal effects on 11 beta-hydroxylation are found. Calmodulin-like activity is present in the mitochondrial preparation. No evidence, however, for a role for calmodulin in the calcium-ADP effects could be obtained, but the possibility of its involvement cannot be excluded. The calcium-ADP modulations are of a magnitude and take place at sufficiently low concentrations to suggest a physiological role in the regulation of mitochondrial steroidogenesis." @default.
• W2023283306 created "2016-06-24" @default.
• W2023283306 creator A5004982119 @default.
• W2023283306 date "1986-02-01" @default.
• W2023283306 modified "2023-09-27" @default.
• W2023283306 title "The stimulation by calcium and its inhibition by adp of cholesterol side-chain cleavage activity in adrenal mitochondria" @default.
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• W2023283306 doi "https://doi.org/10.1016/0022-4731(86)90121-4" @default.
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