Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023285519> ?p ?o ?g. }
- W2023285519 endingPage "2918" @default.
- W2023285519 startingPage "2907" @default.
- W2023285519 abstract "The Department of Medicinal Chemistry, together with the Institute for Structural Biology, Drug Discovery and Development, at Virginia Commonwealth University (VCU) has evolved, organically with quite a bit of bootstrapping, into a unique drug discovery ecosystem in response to the environment and culture of the university and the wider research enterprise. Each faculty member that joined the department and/or institute added a layer of expertise, technology and most importantly, innovation, that fertilized numerous collaborations within the University and with outside partners. Despite moderate institutional support with respect to a typical drug discovery enterprise, the VCU drug discovery ecosystem has built and maintained an impressive array of facilities and instrumentation for drug synthesis, drug characterization, biomolecular structural analysis and biophysical analysis, and pharmacological studies. Altogether, this ecosystem has had major impacts on numerous therapeutic areas, such as neurology, psychiatry, drugs of abuse, cancer, sickle cell disease, coagulopathy, inflammation, aging disorders and others. Novel tools and strategies for drug discovery, design and development have been developed at VCU in the last five decades; e.g., fundamental rational structure-activity relationship (SAR)-based drug design, structure-based drug design, orthosteric and allosteric drug design, design of multi-functional agents towards polypharmacy outcomes, principles on designing glycosaminoglycans as drugs, and computational tools and algorithms for quantitative SAR (QSAR) and understanding the roles of water and the hydrophobic effect." @default.
- W2023285519 created "2016-06-24" @default.
- W2023285519 creator A5003383793 @default.
- W2023285519 creator A5041710956 @default.
- W2023285519 date "2010-04-01" @default.
- W2023285519 modified "2023-10-18" @default.
- W2023285519 title "Chemical sulfation of small molecules—advances and challenges" @default.
- W2023285519 cites W1485174561 @default.
- W2023285519 cites W1499963171 @default.
- W2023285519 cites W1536230526 @default.
- W2023285519 cites W1540414580 @default.
- W2023285519 cites W1563465184 @default.
- W2023285519 cites W1587181662 @default.
- W2023285519 cites W1608374437 @default.
- W2023285519 cites W1849763436 @default.
- W2023285519 cites W189261006 @default.
- W2023285519 cites W1971770416 @default.
- W2023285519 cites W1972864088 @default.
- W2023285519 cites W1973668894 @default.
- W2023285519 cites W1975706192 @default.
- W2023285519 cites W1976343508 @default.
- W2023285519 cites W1977261127 @default.
- W2023285519 cites W1977408028 @default.
- W2023285519 cites W1981891112 @default.
- W2023285519 cites W1982423863 @default.
- W2023285519 cites W1985454669 @default.
- W2023285519 cites W1987111733 @default.
- W2023285519 cites W1989196923 @default.
- W2023285519 cites W1990116971 @default.
- W2023285519 cites W1991359947 @default.
- W2023285519 cites W1994501699 @default.
- W2023285519 cites W1996795546 @default.
- W2023285519 cites W1997196395 @default.
- W2023285519 cites W1997747098 @default.
- W2023285519 cites W1998462395 @default.
- W2023285519 cites W1999330037 @default.
- W2023285519 cites W2000891730 @default.
- W2023285519 cites W2001371234 @default.
- W2023285519 cites W2001535899 @default.
- W2023285519 cites W2001788148 @default.
- W2023285519 cites W2004893313 @default.
- W2023285519 cites W2007948363 @default.
- W2023285519 cites W2008604118 @default.
- W2023285519 cites W2008755388 @default.
- W2023285519 cites W2010679069 @default.
- W2023285519 cites W2012467269 @default.
- W2023285519 cites W2023181523 @default.
- W2023285519 cites W2024483474 @default.
- W2023285519 cites W2025113983 @default.
- W2023285519 cites W2028084357 @default.
- W2023285519 cites W2030723180 @default.
- W2023285519 cites W2031074516 @default.
- W2023285519 cites W2032156966 @default.
- W2023285519 cites W2037974914 @default.
- W2023285519 cites W2039482627 @default.
- W2023285519 cites W2040263894 @default.
- W2023285519 cites W2045214607 @default.
- W2023285519 cites W2048061051 @default.
- W2023285519 cites W2052714318 @default.
- W2023285519 cites W2053071101 @default.
- W2023285519 cites W2055383377 @default.
- W2023285519 cites W2058762300 @default.
- W2023285519 cites W2060512529 @default.
- W2023285519 cites W2061153055 @default.
- W2023285519 cites W2063378545 @default.
- W2023285519 cites W2067441415 @default.
- W2023285519 cites W2068608069 @default.
- W2023285519 cites W2069652714 @default.
- W2023285519 cites W2072354260 @default.
- W2023285519 cites W2074227488 @default.
- W2023285519 cites W2074406878 @default.
- W2023285519 cites W2076938417 @default.
- W2023285519 cites W2078378331 @default.
- W2023285519 cites W2080509103 @default.
- W2023285519 cites W2080941771 @default.
- W2023285519 cites W2091780742 @default.
- W2023285519 cites W2092430704 @default.
- W2023285519 cites W2094289081 @default.
- W2023285519 cites W2106447886 @default.
- W2023285519 cites W2121062485 @default.
- W2023285519 cites W2123408260 @default.
- W2023285519 cites W2124121146 @default.
- W2023285519 cites W2129615851 @default.
- W2023285519 cites W2130238172 @default.
- W2023285519 cites W2139167120 @default.
- W2023285519 cites W2144044805 @default.
- W2023285519 cites W2146373399 @default.
- W2023285519 cites W2152816868 @default.
- W2023285519 cites W2157689651 @default.
- W2023285519 cites W2160715301 @default.
- W2023285519 cites W2163668546 @default.
- W2023285519 cites W2169210630 @default.
- W2023285519 cites W2171548503 @default.
- W2023285519 cites W2176146198 @default.
- W2023285519 cites W2177768443 @default.
- W2023285519 cites W2314619112 @default.
- W2023285519 cites W2314717411 @default.
- W2023285519 cites W2315839415 @default.