FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023286009> ?p ?o ?g. }

• W2023286009 endingPage "169" @default.
• W2023286009 startingPage "169" @default.
• W2023286009 abstract "Recent clinical evidence indicates that the non-eosinophilic subtype of severe asthma is characterized by fixed airway obstruction, which may be related to emphysema. Transgenic studies have demonstrated that high levels of IFN-γ in the airways induce emphysema. Fibroblast growth factor 2 (FGF2), which is the downstream mediator of TGF-β, is important in wound healing. We investigated the role of FGF2 in IFN-γ-induced emphysema and the therapeutic effects of recombinant FGF2 in the prevention of emphysema in a severe non-eosinophilic asthma model. To evaluate the role of FGF2 in IFN-γ-induced emphysema, lung targeted IFN-γ transgenic mice were cross-bred with FGF2-deficient mice. A severe non-eosinophilic asthma model was generated by airway application of LPS-containing allergens twice a week for 4 weeks. To evaluate protective effects of FGF2, recombinant FGF2 (10 µg) was injected subcutaneously during allergen challenge in the severe asthma model. We found that non-eosinophilic inflammation and emphysema induced by transgenic overexpression of IFN-γ in the airways were aggravated by the absence of FGF2. Airway challenge with LPS-containing allergens induced more inflammation in mice sensitized with LPS-containing allergens compared to challenge with allergens alone. In addition, LPS-induced lung inflammation and emphysema depended on IFN-γ but not on IL-13. Interestingly, emphysema in the severe asthma model was significantly inhibited by treatment with recombinant FGF2 during allergen challenge, whereas lung inflammation was unaffected. Therefore, our present data suggest that FGF2 may help protect against IFN-γ-induced emphysema, and that recombinant FGF2 may help lessen the severity of emphysema." @default.
• W2023286009 created "2016-06-24" @default.
• W2023286009 creator A5037420815 @default.
• W2023286009 creator A5043189535 @default.
• W2023286009 creator A5043504900 @default.
• W2023286009 creator A5044481155 @default.
• W2023286009 creator A5054078703 @default.
• W2023286009 creator A5056631863 @default.
• W2023286009 creator A5062150543 @default.
• W2023286009 creator A5064191889 @default.
• W2023286009 creator A5083670127 @default.
• W2023286009 creator A5088682153 @default.
• W2023286009 date "2011-01-01" @default.
• W2023286009 modified "2023-10-10" @default.
• W2023286009 title "Protective effects of basic fibroblast growth factor in the development of emphysema induced by interferon-γ" @default.
• W2023286009 cites W1482666535 @default.
• W2023286009 cites W1539442102 @default.
• W2023286009 cites W1575984269 @default.
• W2023286009 cites W1793014333 @default.
• W2023286009 cites W1794293621 @default.
• W2023286009 cites W1945512486 @default.
• W2023286009 cites W1966105144 @default.
• W2023286009 cites W1966608706 @default.
• W2023286009 cites W1967817926 @default.
• W2023286009 cites W1973840148 @default.
• W2023286009 cites W1981891281 @default.
• W2023286009 cites W1981998280 @default.
• W2023286009 cites W1982140654 @default.
• W2023286009 cites W1988476050 @default.
• W2023286009 cites W1989626763 @default.
• W2023286009 cites W199395634 @default.
• W2023286009 cites W1993997407 @default.
• W2023286009 cites W2027844380 @default.
• W2023286009 cites W2031274702 @default.
• W2023286009 cites W2031674791 @default.
• W2023286009 cites W2059796424 @default.
• W2023286009 cites W2060763719 @default.
• W2023286009 cites W2062182427 @default.
• W2023286009 cites W2069646609 @default.
• W2023286009 cites W2069965475 @default.
• W2023286009 cites W2073310243 @default.
• W2023286009 cites W2075639436 @default.
• W2023286009 cites W2090262871 @default.
• W2023286009 cites W2094742854 @default.
• W2023286009 cites W2106715003 @default.
• W2023286009 cites W2107330389 @default.
• W2023286009 cites W2107875704 @default.
• W2023286009 cites W2115163495 @default.
• W2023286009 cites W2121394744 @default.
• W2023286009 cites W2121449552 @default.
• W2023286009 cites W2131713008 @default.
• W2023286009 cites W2132381574 @default.
• W2023286009 cites W2136199835 @default.
• W2023286009 cites W2145488426 @default.
• W2023286009 cites W2150035260 @default.
• W2023286009 cites W2161669060 @default.
• W2023286009 cites W2759566626 @default.
• W2023286009 cites W4254570903 @default.
• W2023286009 doi "https://doi.org/10.3858/emm.2011.43.4.018" @default.
• W2023286009 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3085735" @default.
• W2023286009 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21297377" @default.
• W2023286009 hasPublicationYear "2011" @default.
• W2023286009 type Work @default.
• W2023286009 sameAs 2023286009 @default.
• W2023286009 citedByCount "29" @default.
• W2023286009 countsByYear W20232860092012 @default.
• W2023286009 countsByYear W20232860092013 @default.
• W2023286009 countsByYear W20232860092014 @default.
• W2023286009 countsByYear W20232860092015 @default.
• W2023286009 countsByYear W20232860092016 @default.
• W2023286009 countsByYear W20232860092017 @default.
• W2023286009 countsByYear W20232860092018 @default.
• W2023286009 countsByYear W20232860092019 @default.
• W2023286009 countsByYear W20232860092020 @default.
• W2023286009 countsByYear W20232860092021 @default.
• W2023286009 countsByYear W20232860092022 @default.
• W2023286009 countsByYear W20232860092023 @default.
• W2023286009 crossrefType "journal-article" @default.
• W2023286009 hasAuthorship W2023286009A5037420815 @default.
• W2023286009 hasAuthorship W2023286009A5043189535 @default.
• W2023286009 hasAuthorship W2023286009A5043504900 @default.
• W2023286009 hasAuthorship W2023286009A5044481155 @default.
• W2023286009 hasAuthorship W2023286009A5054078703 @default.
• W2023286009 hasAuthorship W2023286009A5056631863 @default.
• W2023286009 hasAuthorship W2023286009A5062150543 @default.
• W2023286009 hasAuthorship W2023286009A5064191889 @default.
• W2023286009 hasAuthorship W2023286009A5083670127 @default.
• W2023286009 hasAuthorship W2023286009A5088682153 @default.
• W2023286009 hasBestOaLocation W20232860091 @default.
• W2023286009 hasConcept C104317684 @default.
• W2023286009 hasConcept C126322002 @default.
• W2023286009 hasConcept C170493617 @default.
• W2023286009 hasConcept C203014093 @default.
• W2023286009 hasConcept C207480886 @default.
• W2023286009 hasConcept C2776042228 @default.
• W2023286009 hasConcept C2776914184 @default.
• W2023286009 hasConcept C2777714996 @default.
• W2023286009 hasConcept C40767141 @default.

• next