Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023286560> ?p ?o ?g. }
Showing items 1 to 81 of
81
with 100 items per page.
- W2023286560 endingPage "98" @default.
- W2023286560 startingPage "98" @default.
- W2023286560 abstract "Liver disease of variable severity occurs in only 20% of children with PiZ phenotype. To investigate whether such variability is due to immunogenetic factors we have determined HLA phenotypes of 43 unrelated PiZ children with CLD. 36 classl [A & B] were determined in all patients and 63 controls, and 9 class II(DR) antigens were determined in 33 patients and 47 controls. Haplotypes were obtained by studying family members. Significant differences between patients and controls were limited to B5 which was absent in patients but present in 8 controls [12.6%, p =0.0475] and DR3 which was found more frequently in patients [19 (57.6%) compared with 14 controls (29.8%), X2=5.084, p<0.025, relative risk = 3.20]. Although DR3 is in strong allelic association with Al & B8 the frequency of these antigens in patients [Al: 1] of 43(25.6%) and B8: 11 of 43(25.6%) were similar to that in the controls. The frequency of haplotypes A1-B8 [5 of 64, 7.8%] and B8-DR3 [4 of 36, 11.1%] in patients were similar to the findings in 8th International HLA Workshop. It is possible that B5 confers protection against liver disease in AATd whereas DR3 increases susceptibility. Thus, an immunoregulatory gene may influence the clinical outcome of AATd. Lack of increase in Al or B8 despite an increase in DR3 suggests a genetic base different to that usually associated with autoimmunity." @default.
- W2023286560 created "2016-06-24" @default.
- W2023286560 creator A5011497420 @default.
- W2023286560 creator A5029193603 @default.
- W2023286560 creator A5046470723 @default.
- W2023286560 creator A5051135113 @default.
- W2023286560 creator A5052366492 @default.
- W2023286560 creator A5053927624 @default.
- W2023286560 creator A5061280861 @default.
- W2023286560 date "1987-07-01" @default.
- W2023286560 modified "2023-10-18" @default.
- W2023286560 title "12. HLA STATUS IN CHILDREN WITH ALPHA-1 ANTITRYPSIN DEFICIENCY(AATd)(PiZ) & CHRONIC LIVER DISEASE (CLD)" @default.
- W2023286560 doi "https://doi.org/10.1203/00006450-198707000-00033" @default.
- W2023286560 hasPublicationYear "1987" @default.
- W2023286560 type Work @default.
- W2023286560 sameAs 2023286560 @default.
- W2023286560 citedByCount "2" @default.
- W2023286560 crossrefType "journal-article" @default.
- W2023286560 hasAuthorship W2023286560A5011497420 @default.
- W2023286560 hasAuthorship W2023286560A5029193603 @default.
- W2023286560 hasAuthorship W2023286560A5046470723 @default.
- W2023286560 hasAuthorship W2023286560A5051135113 @default.
- W2023286560 hasAuthorship W2023286560A5052366492 @default.
- W2023286560 hasAuthorship W2023286560A5053927624 @default.
- W2023286560 hasAuthorship W2023286560A5061280861 @default.
- W2023286560 hasBestOaLocation W20232865601 @default.
- W2023286560 hasConcept C104317684 @default.
- W2023286560 hasConcept C126322002 @default.
- W2023286560 hasConcept C127716648 @default.
- W2023286560 hasConcept C147483822 @default.
- W2023286560 hasConcept C180754005 @default.
- W2023286560 hasConcept C188280979 @default.
- W2023286560 hasConcept C197754878 @default.
- W2023286560 hasConcept C203014093 @default.
- W2023286560 hasConcept C2777075537 @default.
- W2023286560 hasConcept C2777214474 @default.
- W2023286560 hasConcept C2779102576 @default.
- W2023286560 hasConcept C2779134260 @default.
- W2023286560 hasConcept C2780535462 @default.
- W2023286560 hasConcept C54355233 @default.
- W2023286560 hasConcept C71924100 @default.
- W2023286560 hasConcept C86803240 @default.
- W2023286560 hasConcept C90924648 @default.
- W2023286560 hasConceptScore W2023286560C104317684 @default.
- W2023286560 hasConceptScore W2023286560C126322002 @default.
- W2023286560 hasConceptScore W2023286560C127716648 @default.
- W2023286560 hasConceptScore W2023286560C147483822 @default.
- W2023286560 hasConceptScore W2023286560C180754005 @default.
- W2023286560 hasConceptScore W2023286560C188280979 @default.
- W2023286560 hasConceptScore W2023286560C197754878 @default.
- W2023286560 hasConceptScore W2023286560C203014093 @default.
- W2023286560 hasConceptScore W2023286560C2777075537 @default.
- W2023286560 hasConceptScore W2023286560C2777214474 @default.
- W2023286560 hasConceptScore W2023286560C2779102576 @default.
- W2023286560 hasConceptScore W2023286560C2779134260 @default.
- W2023286560 hasConceptScore W2023286560C2780535462 @default.
- W2023286560 hasConceptScore W2023286560C54355233 @default.
- W2023286560 hasConceptScore W2023286560C71924100 @default.
- W2023286560 hasConceptScore W2023286560C86803240 @default.
- W2023286560 hasConceptScore W2023286560C90924648 @default.
- W2023286560 hasIssue "1" @default.
- W2023286560 hasLocation W20232865601 @default.
- W2023286560 hasOpenAccess W2023286560 @default.
- W2023286560 hasPrimaryLocation W20232865601 @default.
- W2023286560 hasRelatedWork W1562771806 @default.
- W2023286560 hasRelatedWork W1607797762 @default.
- W2023286560 hasRelatedWork W1972188791 @default.
- W2023286560 hasRelatedWork W2023286560 @default.
- W2023286560 hasRelatedWork W2041686821 @default.
- W2023286560 hasRelatedWork W2091803012 @default.
- W2023286560 hasRelatedWork W2148441798 @default.
- W2023286560 hasRelatedWork W2427947769 @default.
- W2023286560 hasRelatedWork W2540336298 @default.
- W2023286560 hasRelatedWork W2805640416 @default.
- W2023286560 hasVolume "22" @default.
- W2023286560 isParatext "false" @default.
- W2023286560 isRetracted "false" @default.
- W2023286560 magId "2023286560" @default.
- W2023286560 workType "article" @default.